DSIP

DSIP (10mg) — Delta Sleep-Inducing Nonapeptide Research Compound

DSIP (10mg) is stocked in Australia by Omega Peptides Australia and dispatched the same business day on orders before 12pm, each batch backed by an independent certificate of analysis. Also searched as delta sleep-inducing peptide, delta sleep inducing peptide or DSIP peptide, it is a nonapeptide studied for sleep architecture and hypothalamic stress-axis regulation.

DSIP, or delta sleep-inducing peptide, is a naturally occurring nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, written in single-letter code as WAGGDASGE. It was first isolated in the 1970s by the Swiss Schoenenberger-Monnier group from the cerebral venous blood of rabbits during electrically induced slow-wave sleep, and it takes its name from the delta-wave EEG activity it was reported to promote when infused into recipient animals. DSIP has since been found in many tissues and body fluids, including the hypothalamus, pituitary, plasma and milk, and carries the international non-proprietary name emideltide. It is often written as DSIP peptide, dsip 10mg or delta sleep peptide.

DSIP is studied principally for its influence on sleep architecture and slow-wave EEG activity, for modulation of the stress axis and stress-related behaviour, and for its actions in pain and opioid-withdrawal models. Despite decades of work, no dedicated DSIP receptor has been identified; the peptide is proposed to act through modulation of NMDA and GABA-related transmission, interactions with opioid and adrenergic systems, and regulation of stress-responsive gene expression, with its own production in turn regulated by glucocorticoids.

Omega Peptides Australia supplies DSIP as a high-purity (≥99% HPLC) COA-verified lyophilised powder in a sealed sterile 10mg vial. Orders placed before 12pm are dispatched the same day from within Australia, and the certificate for every batch is published in our COA library.

Key research areas

• Sleep architecture and slow-wave activity The original DSIP studies measured EEG delta power in rabbits and rats after peptide infusion, and later work in rodents examined total sleep time, sleep latency and the balance of slow-wave and REM sleep. The proposed mechanism involves modulation of thalamocortical rhythms through GABAergic and glutamatergic circuits rather than direct sedation, and results vary considerably with species, timing and route.
• Stress and the hypothalamic-pituitary-adrenal axis DSIP is investigated for its ability to blunt stress-induced rises in ACTH and corticosterone in rodent models of restraint, cold and emotional stress. Researchers examine whether the peptide normalises the HPA axis rather than suppressing it outright, and how glucocorticoids in turn regulate DSIP-like immunoreactivity.
• Pain and opioid withdrawal In rodent models DSIP has been studied for antinociceptive activity and for attenuating the behavioural and autonomic signs of opioid and alcohol withdrawal. The mechanism is proposed to involve interaction with opioid receptor systems and modulation of monoaminergic transmission, and DSIP has been reported to act antagonistically to opioid dependence rather than as an opioid agonist.
• Oxidative stress and mitochondrial function DSIP and its analogues have been examined as antioxidant peptides in tissue and cell models, with reports of reduced lipid peroxidation, stabilised mitochondrial membranes and improved cell survival under oxidative and hypoxic challenge, particularly in ageing-related research.
• Circadian rhythm and thermoregulation Because DSIP-like immunoreactivity fluctuates with the light-dark cycle, it is studied as a possible signal linking circadian timing to sleep pressure and body temperature. Rodent studies track locomotor rhythms, core temperature and hormone secretion after peptide administration at different circadian phases.
• Analogue design and stability Native DSIP is degraded within minutes by aminopeptidases, so synthetic analogues with modified residues have been developed and compared with the parent peptide for potency and duration in sleep and stress assays. DSIP is the reference compound in this structure-activity research.

DSIP in Australia

Because DSIP is not listed on the Australian Register of Therapeutic Goods, it cannot be bought from a pharmacy in Australia; retail chains do not carry it. The route in Australia is a domestic research supplier holding the compound as a research-grade lyophilised vial. Omega Peptides Australia keeps DSIP in Australian stock and ships it the same business day for orders before 12pm, on tracked delivery, which removes the transit and customs delay of ordering from overseas. The batch certificate is published in the COA library so identity and purity can be checked before the order is placed. Browse the full range of research peptides in Australia on our homepage.

DSIP is stocked in Australia as a 10mg vial. Researchers in the neurological range often hold it alongside Selank and Semax, both in domestic stock.

How DSIP works

DSIP is unusual among research neuropeptides in that its receptor has never been cloned, and its reported effects in rodent models are thought to arise from several converging actions rather than one binding event. It is proposed to modulate NMDA receptor activity and GABAergic transmission in thalamocortical circuits that generate delta rhythms, to interact with opioid and alpha-1 adrenergic systems, and to influence acetylcholine turnover in the brain. At the level of gene regulation, DSIP shares sequence features with a glucocorticoid-induced leucine zipper protein and is proposed to interact with MAPK signalling, offering a possible explanation for its stress-buffering effects. Its own levels are regulated by glucocorticoids, suggesting a feedback role within the stress axis.

Pharmacokinetically, DSIP is a small hydrophilic peptide with a molecular weight of about 849 daltons. In vitro it has a half-life of only about 15 minutes because of rapid aminopeptidase cleavage, yet it is detected in the brain after peripheral administration in animals and is thought to travel bound to carrier proteins that shield it from degradation. This contrasts with Selank, a tuftsin-derived heptapeptide studied in anxiety models that acts through GABA-related and immune signalling, and with Epitalon, a tetrapeptide studied in circadian and telomerase research. DSIP remains the compound of choice when the research question concerns slow-wave sleep and the sleep-stress interface.

Specifications

Available sizes and pricing

DSIP is supplied in a single 10mg lyophilised vial. As a short, readily synthesised nonapeptide, it is one of the more economical compounds in our neuropeptide range and is frequently ordered alongside Selank or Semax for stress and sleep research panels.

• 10mg vial — $89.99 (about $9.00 per mg)

Multi-vial pricing: 2 vials $161.98 (10% off, $80.99 each), 3 vials $236.22 (12.5% off, $78.74 each), 4 vials $305.97 (15% off, $76.49 each). The discount is applied automatically in the cart.

Laboratories building a broader panel may also consider the Semax and Selank Bundle, which pairs two related neuropeptides at a bundle price.

Quality and COA verification

Every batch of DSIP is tested independently by Janoshik Analytical. HPLC quantifies purity against the ≥99% specification and mass spectrometry confirms that the observed mass matches the expected 848.82 g/mol for the full nine-residue sequence, ruling out truncated or deletion sequences that can arise during synthesis. A Certificate of Analysis is issued for every lot and published in our COA library, where the batch number on your vial can be matched to its report. Because DSIP is degraded so quickly in solution, it is supplied lyophilised, sealed in a sterile vial under an inert environment, and packed with cushioning for domestic transit so that it arrives in the same condition it left our facility.

Frequently bought together

• Selank (10mg) — $79.99, the anxiolytic-type heptapeptide most often paired with DSIP in stress research
• Epitalon (10mg) — $79.99, a tetrapeptide studied in circadian and ageing models
• Semax (10mg) — $79.99, a BDNF-linked nootropic peptide for cognition panels
• Bacteriostatic Water (10mL) — $29.99, for reconstituting the lyophilised powder

Research guides

• Peptide storage guide: how to store lyophilised peptides properly
• COA testing explained
• Peptide reconstitution calculator
• Certificates of Analysis library

Frequently asked questions

What is DSIP?
DSIP, delta sleep-inducing peptide, is a naturally occurring nine-amino-acid peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated from rabbit cerebral venous blood during induced slow-wave sleep in the 1970s. It is studied in rodent and in-vitro models for its effects on sleep EEG, the stress axis, pain and opioid withdrawal, and oxidative stress. It is supplied here as a lyophilised research powder for in-vitro and laboratory use only.

What is DSIP also known as?
It is also written as DSIP peptide, dsip 10mg or delta sleep peptide, and its full name is delta sleep-inducing peptide. Its international non-proprietary name is emideltide, and it appears in chemical databases under CAS number 62568-57-4 with the single-letter sequence WAGGDASGE. All of these refer to the same nonapeptide.

How does DSIP work?
No specific DSIP receptor has been identified. Research suggests it acts through several converging mechanisms: modulation of NMDA and GABA-related transmission in the thalamocortical circuits that generate delta rhythms, interaction with opioid and alpha-1 adrenergic systems, influence on brain acetylcholine turnover, and regulation of stress-responsive signalling through a MAPK-linked pathway. Its own levels are regulated by glucocorticoids, suggesting a feedback role in the stress axis.

What does the research show about DSIP?
Rodent and rabbit studies since the 1970s report increased delta-wave EEG activity and altered sleep patterns, reduced stress-induced ACTH and corticosterone release, antinociceptive effects and attenuation of opioid-withdrawal signs. Antioxidant activity has been reported in tissue and cell models. Findings are inconsistent across species and protocols, and the mechanism remains unresolved, which is why reviewers still describe DSIP as a scientific riddle.

Can I buy DSIP at Chemist Warehouse or a pharmacy in Australia?
No. DSIP is not a registered medicine in Australia or in any major regulatory jurisdiction, is not on the Australian Register of Therapeutic Goods, and is not stocked by Chemist Warehouse, Priceline or any other retail pharmacy. In Australia it is available only as a research-grade lyophilised peptide from laboratory suppliers, supplied for in-vitro and laboratory use.

Can Australian compounding pharmacies supply DSIP?
Compounding pharmacies in Australia may only prepare a medicine for an individual patient on prescription, and the TGA has highlighted significant uncertainties with compounded unapproved peptides whose active ingredients are not described in recognised compounding references. DSIP has no such reference, no pharmacopoeial monograph and no approved indication, so it is not a compounding product. Research suppliers such as Omega Peptides Australia supply the lyophilised research peptide for laboratory use only.

How do you reconstitute DSIP?
Use bacteriostatic water. Draw the required volume into a sterile syringe and add it slowly down the inside wall of the vial rather than onto the powder, then swirl gently until the solution is clear; never shake. DSIP dissolves readily because it is a small hydrophilic peptide. Refrigerate the reconstituted vial at 2–8°C and use within 28 days, and keep in mind that DSIP degrades faster in solution than most peptides.

How should DSIP be stored?
Keep the sealed lyophilised vial at 2–8°C for short-term storage or at −20°C for long-term storage, protected from light and moisture, and avoid repeated freeze-thaw cycles. Once reconstituted, store the solution at 2–8°C and use within 28 days. DSIP is particularly sensitive to peptidase degradation once in solution, so only reconstitute what a study will consume in that window.

Where can I buy DSIP in Australia?
Omega Peptides Australia holds DSIP in domestic stock, dispatches orders placed before 12pm the same day, and publishes a batch Certificate of Analysis for every vial. Buying from an Australian supplier avoids international transit delays and the temperature exposure that can degrade a peptide as fragile as DSIP. You can browse it with our other neuropeptides in the research peptides Australia collection.

What does DSIP cost in Australia?
The 10mg lyophilised vial is $89.99, which is about $9.00 per mg. That places DSIP among the more affordable peptides in our neuropeptide range, reflecting its short nine-residue sequence and straightforward synthesis. All prices are in Australian dollars and include third-party HPLC and mass spectrometry testing, with the batch report available in our COA library.

How do I get DSIP online in Australia?
Select the 10mg vial on this page, add it to your cart and complete checkout. Orders are shipped with tracked domestic delivery in discreet packaging with no reference to the contents. Orders placed before 12pm on a business day are dispatched the same day; later orders leave the following business day, and tracking details are emailed once the parcel is lodged.

Is DSIP legal in Australia?
Omega Peptides Australia supplies DSIP strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine or supplement. Purchasers are responsible for ensuring their intended use complies with all applicable laws.

DSIP vs Selank: two peptides studied in stress and sleep research, how do they differ?
DSIP is a naturally occurring nonapeptide isolated from mammalian blood and studied chiefly for slow-wave sleep and stress-axis modulation, with no identified receptor. Selank is a synthetic heptapeptide derived from the immune peptide tuftsin, studied mainly in anxiety and cognition models and thought to act through GABA-related transmission, serotonin metabolism and immune signalling. They are complementary rather than interchangeable, and many laboratories study them together in stress research panels.

Is DSIP available in Australia?
Yes, as a research-grade lyophilised peptide from domestic suppliers. Omega Peptides Australia holds DSIP 10mg in Australian stock, COA verified, with same-day dispatch before 12pm.

Where can I buy DSIP peptide in Australia?
From an Australian research peptide supplier holding domestic stock. Omega Peptides Australia dispatches DSIP from within Australia on tracked delivery.

⚠ For in-vitro research and laboratory use only. Not for human or veterinary use.