N-Acetyl Selank

N-Acetyl Selank (10mg) — Acetylated Tuftsin Analogue Anxiolytic Research Peptide

N-Acetyl Selank (10mg) is stocked in Australia by Omega Peptides Australia and dispatched the same business day on orders before 12pm, each batch backed by an independent certificate of analysis. Also searched as NA-Selank, NA Selank or acetyl selank, it is the N-terminally acetylated analogue of Selank studied for extended anxiolytic activity.

N-Acetyl Selank is the N-terminally acetylated derivative of Selank, the tuftsin-analogue heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It keeps the Thr-Lys-Pro-Arg-Pro-Gly-Pro backbone, in which the immune tetrapeptide tuftsin is extended with a Pro-Gly-Pro tail, but an acetyl group caps the free amine of the N-terminal threonine. Research catalogues frequently list the compound as N-Acetyl Selank amidate, indicating that the supplied form also carries a C-terminal amide. It is written as NA-Selank, NA Selank, acetyl selank or n acetyl selank.

The compound is studied in the same directions as Selank: anxiety and stress responses, learning and memory, and immune modulation, with the added question of how the acetyl cap changes stability and tissue persistence. Mechanistically it is understood to act through the Selank pathways, altering the expression of genes involved in GABAergic neurotransmission, inhibiting enkephalin-degrading enzymes and raising hippocampal BDNF, rather than through any new target introduced by the modification.

Omega Peptides Australia supplies N-Acetyl Selank as a high-purity (≥99% HPLC) COA-verified lyophilised powder in a sealed 10mg vial. Orders placed before 12pm are dispatched the same day from within Australia, and the batch Certificate of Analysis for every lot is published in our COA library.

Key research areas

• Peptide stability and degradation The acetyl modification is itself a research subject. Unmodified Selank is trimmed from the N-terminus by aminopeptidases in serum and tissue, and N-Acetyl Selank is used to examine how blocking that first cleavage changes the persistence of the intact peptide and the fragments produced.
• Anxiety and stress responses Selank shows anxiolytic-like behaviour in rodent elevated plus-maze and open-field paradigms without the sedation associated with benzodiazepines. The acetylated form is studied in the same paradigms where a longer-lived peptide is wanted.
• GABAergic neurotransmission Gene-expression work in rodent brain shows Selank alters transcription of genes involved in GABAergic signalling, including GABA-A receptor subunits. N-Acetyl Selank preserves the sequence responsible and is investigated on the same basis.
• Enkephalin degradation Selank inhibits enkephalin-degrading enzymes in human serum in vitro, a proposed mechanism for its behavioural effects. Because the acetyl group sits on the terminal amine rather than a side chain, this activity is expected to be retained in the acetylated form.
• Learning and memory Rodent studies of Selank report improved consolidation in conditioned-response and maze tasks, attributed to increased hippocampal BDNF. N-Acetyl Selank is used in extensions of this work.
• Immune modulation The tuftsin core gives the Selank family immunomodulatory activity, including effects on interleukin-6 expression and T helper cytokine balance, and the acetylated analogue is examined in the same models.

How N-Acetyl Selank works

N-Acetyl Selank acts through the pathways described for Selank. Its anxiolytic-like activity in animal models is attributed mainly to changes in GABAergic transmission, with the peptide altering the expression of genes encoding GABA-A receptor subunits and related proteins, and it has been proposed to modulate GABA-A receptor function in a way that complements rather than duplicates the action of benzodiazepines. In parallel the Selank sequence inhibits enkephalin-degrading enzymes, prolonging the activity of endogenous enkephalins involved in stress and pain regulation, increases BDNF expression in the hippocampus and shifts serotonin metabolism. The tuftsin core also contributes immunomodulatory activity.

The acetyl group changes how long the peptide survives rather than what it does. Aminopeptidases remove residues from a free N-terminus, and acetylation removes the free amine those enzymes require; the C-terminal amide present in the amidate form removes the free carboxyl group that carboxypeptidases act on, so the modified peptide resists degradation from both ends. This is the same principle that separates N-Acetyl Semax from Semax. Compared with unmodified Selank, the acetylated form is expected to persist longer in biological samples, at the cost of a smaller published evidence base, since most primary research was conducted with the parent peptide.

Specifications

Available sizes and pricing

N-Acetyl Selank is supplied in a single 10mg vial. The unmodified parent peptide, Selank, is available separately at a lower per-mg cost, and the two are often purchased together for direct comparison work.

• 10mg vial — $129.99 (about $13.00 per mg)

Quality and COA verification

Every batch of N-Acetyl Selank is tested independently by Janoshik Analytical. HPLC quantifies purity, and mass spectrometry confirms that the measured molecular mass matches the acetylated sequence rather than unmodified Selank, the check that matters most for a derivative differing from its parent by a single acetyl group. A Certificate of Analysis is issued for each batch and published in our COA library, so a vial's lot number can be matched to its own report before it is opened. The peptide is supplied as a lyophilised powder in a sealed sterile vial, which protects it from hydrolysis during storage and transit, and every order is packed with protective cushioning for domestic delivery within Australia.

Frequently bought together

• Bacteriostatic Water (10mL) — $29.99, the recommended diluent for reconstituting lyophilised N-Acetyl Selank
• Selank (10mg) — $79.99, the unmodified parent peptide for side-by-side stability and activity comparisons
• N-Acetyl Semax (10mg) — $129.99, the acetylated ACTH-derived peptide studied alongside it in cognition and stress models
• Semax (10mg) — $79.99, the unmodified companion peptide sharing the Pro-Gly-Pro tail

Research guides

• Semax Australia research guide
• Peptide storage guide: how to store lyophilised peptides properly
• COA testing explained for research peptides
• Peptide reconstitution calculator

Frequently asked questions

What is NA-Selank?
NA-Selank is the common shorthand for N-Acetyl Selank, the acetylated derivative of the Russian anxiolytic research peptide Selank. The "NA" stands for N-acetyl, describing the acetyl group attached to the N-terminal threonine. When a supplier lists NA-Selank amidate, the name also indicates a C-terminal amide. All of these refer to the same research compound supplied here as a lyophilised 10mg vial for in-vitro laboratory use only.

What is N-Acetyl Selank?
N-Acetyl Selank is a synthetic heptapeptide with the sequence Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro, an acetylated form of Selank, which is itself an analogue of the immune peptide tuftsin with a Pro-Gly-Pro tail. The acetyl cap makes the peptide more resistant to enzymatic breakdown. It is studied as an anxiolytic and nootropic research compound in models of stress, memory and immune function, and it is supplied strictly for laboratory research.

What is N-Acetyl Selank also known as?
It is written as NA-Selank, NA Selank, acetyl selank, n acetyl selank or Ac-Selank, and research catalogues frequently list it as N-Acetyl Selank amidate or NA-Selank amidate to indicate the C-terminal amide. Published CAS registrations for the acetylated form are inconsistent between suppliers, so identity is best confirmed from the mass spectrometry result on the batch COA. It should not be confused with plain Selank, CAS 129954-34-3.

How does N-Acetyl Selank work?
It acts through the pathways described for Selank: altered expression of genes involved in GABAergic neurotransmission, inhibition of enkephalin-degrading enzymes, increased BDNF expression in the hippocampus, changes in serotonin metabolism and immunomodulatory effects from the tuftsin core. The acetyl group does not add a new target; it blocks aminopeptidases at the N-terminus so the intact peptide persists longer in tissue and serum, and the amidated C-terminus adds protection against carboxypeptidases.

What does the research show about N-Acetyl Selank?
The published evidence base belongs largely to unmodified Selank, which in rodent models has shown anxiolytic-like behaviour without sedation, improved memory consolidation, changes in GABA-related gene expression, inhibition of enkephalin-degrading enzymes and effects on interleukin-6 expression. N-Acetyl Selank is used in research that builds on those findings where a more stable analogue is wanted, and stability comparisons between the two forms are a study area in their own right. The acetylated form has no clinical registration anywhere.

Can I buy N-Acetyl Selank at Chemist Warehouse or a pharmacy in Australia?
No. N-Acetyl Selank is not registered on the Australian Register of Therapeutic Goods, so it is not stocked by Chemist Warehouse, Priceline or any other retail pharmacy, and no Australian medicine contains it. Unlike Selank, which is sold as a nasal product in Russian pharmacies, the acetylated derivative has no pharmaceutical registration in any country. The lyophilised compound supplied here is a research-grade chemical for laboratory use, not a medicine.

Can Australian compounding pharmacies supply N-Acetyl Selank?
Compounding pharmacies in Australia may only prepare a medicine for a named patient against a valid prescription, and the TGA has issued specific guidance warning pharmacists about compounding and supplying unapproved peptide products. N-Acetyl Selank is not an approved medicine, so it is not a routine compounding item. Research suppliers such as Omega Peptides Australia provide the lyophilised research compound, which is a different product intended for in-vitro work rather than for dispensing to patients.

How do you reconstitute N-Acetyl Selank?
Let the vial reach room temperature, then add bacteriostatic water slowly down the inside wall of the vial so the stream does not hit the powder directly. Swirl gently until the solution is clear and do not shake, since agitation can damage the peptide. The volume of diluent depends on the concentration the research design calls for; our reconstitution calculator can help. Refrigerate the solution at 2–8°C and use it within 28 days.

How should N-Acetyl Selank be stored?
Store the sealed lyophilised powder at 2–8°C for short-term use or at −20°C for long-term storage, protected from light and moisture, and avoid repeated freeze-thaw cycles. Once reconstituted, keep the solution refrigerated at 2–8°C and use it within 28 days. The lysine and arginine residues make the powder hygroscopic, so keep the vial sealed until it is needed and return it to the refrigerator promptly after use.

Where can I buy N-Acetyl Selank in Australia?
N-Acetyl Selank 10mg is available directly from Omega Peptides Australia. Stock is held domestically, orders placed before 12pm are dispatched the same day, and every batch is supported by an independent Certificate of Analysis you can review before ordering. The peptide is listed in our research peptides collection alongside Selank, Semax and N-Acetyl Semax.

What does N-Acetyl Selank cost in Australia?
N-Acetyl Selank is $129.99 for a 10mg vial from Omega Peptides Australia, which is about $13.00 per mg. The higher price relative to Selank at $79.99 reflects the additional synthesis steps of the acetylated form. There is currently no bundle containing N-Acetyl Selank; the Semax and Selank Bundle uses the unmodified peptides. Prices are in Australian dollars, with domestic tracked shipping calculated at checkout.

How do I get N-Acetyl Selank online in Australia?
Open the N-Acetyl Selank product page, select the 10mg vial, add it to your cart and complete checkout. Orders ship with tracked domestic delivery in discreet, unbranded packaging that gives no indication of the contents. Orders placed before 12pm on a business day leave the same day, and later orders are dispatched the next business day. Tracking details are emailed once the parcel is lodged.

Is N-Acetyl Selank legal in Australia?
Omega Peptides Australia supplies N-Acetyl Selank strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine or supplement. Purchasers are responsible for ensuring their intended use complies with all applicable laws. This research-only condition applies to every compound in our catalogue and is stated on each product page and on the COA documentation.

N-Acetyl Selank vs Selank: what is the difference?
Both share the Thr-Lys-Pro-Arg-Pro-Gly-Pro sequence and the same GABAergic, enkephalin and neurotrophin targets. The difference is chemical: N-Acetyl Selank has an acetyl cap on the N-terminus (and, in the amidate form, an amide on the C-terminus) that blocks the enzymes responsible for trimming Selank, so it degrades more slowly. Selank has the larger published evidence base and the lower price; the acetylated form suits work needing a longer-lived peptide. See the Selank page for its specifications.

⚠ For in-vitro research and laboratory use only. Not for human or veterinary use.