Ipamorelin

Ipamorelin (10mg) — Selective Growth Hormone Secretagogue Research Peptide

Ipamorelin (10mg) is supplied in Australia by Omega Peptides Australia from domestic stock, with same-day dispatch on orders placed before 12pm and an independent certificate of analysis for every batch. Commonly written as ipamorelin peptide, Ipa, ipamoralin, ipamorelon, ghrelin receptor agonist or GHRP, it is a selective ghrelin-receptor agonist studied for pulsatile growth hormone release.

Ipamorelin is a synthetic pentapeptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2, built around an aminoisobutyric acid residue and two D-amino acids that make it resistant to enzymatic breakdown. It was developed by Novo Nordisk under the code NNC 26-0161 as a refinement of the earlier growth hormone-releasing peptide GHRP-1, and it belongs to the ghrelin-mimetic class of secretagogues rather than the GHRH-analogue class. It is often written as ipamorelin peptide or shortened to Ipa, and the misspelling ipamoralin is common.

Ipamorelin is studied for selective growth hormone release, for the pharmacology of the ghrelin receptor, and as the ghrelin-pathway component in combination models with GHRH analogues. It is an agonist of the growth hormone secretagogue receptor GHS-R1a, the same receptor that the gut hormone ghrelin activates; on pituitary somatotrophs this triggers calcium-mediated release of growth hormone, and in the hypothalamus it reduces somatostatin tone. What sets ipamorelin apart from older ghrelin mimetics is that it stimulates growth hormone without meaningful release of cortisol, ACTH or prolactin.

Omega Peptides Australia supplies ipamorelin as a high-purity (≥99% HPLC) COA-verified lyophilised powder in a 10mg vial, dispatched same day from within Australia on orders placed before 12pm. Every batch is independently tested and the certificate for your vial can be reviewed in our COA library before you order.

Key research areas

• Selective growth hormone release Ipamorelin is the reference compound for studying growth hormone secretion that is separated from stress-hormone release. Preclinical and early clinical work reported growth hormone pulses comparable to those produced by GHRP-6 without the accompanying rise in cortisol, ACTH or prolactin, which makes it the cleanest tool for isolating the ghrelin-receptor contribution to GH output.
• Ghrelin-receptor pharmacology As a well-characterised GHS-R1a agonist, ipamorelin is used in receptor-binding, signalling and desensitisation studies, including work on how repeated stimulation changes receptor sensitivity and on the receptor's role outside the pituitary.
• Combination secretagogue research Because GHRH analogues and ghrelin mimetics act through different receptors on the same cells, ipamorelin is routinely paired with Modified GRF (1-29) or CJC-1295 DAC to study amplified, pulsatile growth hormone release. The CJC-1295 No DAC and Ipamorelin blend supplies that pairing in one vial.
• Gastrointestinal motility research Ghrelin-receptor agonists influence gastric emptying and intestinal transit, and ipamorelin was taken into Phase 2 clinical trials for post-operative ileus before that programme was discontinued. It remains a model compound in preclinical motility research.
• Bone and body-composition research Growth hormone and IGF-1 influence bone turnover, lean mass and fat metabolism, and ipamorelin has been examined in rodent models of bone formation and body composition, including studies in glucocorticoid-treated animals.
• Appetite and energy-balance research Ghrelin is the main appetite-stimulating hormone, and ipamorelin is used to study which ghrelin-receptor effects on feeding and energy balance are shared by synthetic agonists, given that it appears to have weaker orexigenic effects than GHRP-6.

Ipamorelin in Australia

Ipamorelin is not registered on the Australian Register of Therapeutic Goods, so it is not stocked by Chemist Warehouse, Priceline or other pharmacies. In Australia it is supplied as a research-grade lyophilised vial by domestic research suppliers. Omega Peptides Australia holds Ipamorelin in stock within Australia and dispatches orders placed before 12pm the same business day on tracked domestic delivery, so material arrives in days rather than waiting on an international shipment and customs. Every batch is tested independently and its certificate is published in the COA library before the vial ships.

Ipamorelin is most often run in Australia either on its own or pre-blended with a GHRH analogue as the CJC-1295 No DAC + Ipamorelin blend. Both are held in domestic stock.

How Ipamorelin works

Growth hormone release from the pituitary is controlled by three inputs: GHRH stimulates it, somatostatin inhibits it, and ghrelin amplifies it through the growth hormone secretagogue receptor GHS-R1a. Ipamorelin is a synthetic agonist of that receptor. When it binds GHS-R1a on somatotroph cells, the receptor couples to Gq proteins and activates phospholipase C, which raises inositol trisphosphate and releases calcium from intracellular stores, and the calcium surge triggers exocytosis of growth hormone-containing granules. In the hypothalamus, ipamorelin also stimulates GHRH-releasing neurons and reduces somatostatin output, so it acts at two levels of the axis. Because the GHRH receptor signals through cyclic AMP rather than calcium, combining ipamorelin with a GHRH analogue produces a larger response than either pathway alone.

Ipamorelin has an elimination half-life of about two hours, which is long enough to produce a full growth hormone pulse but short enough to preserve the normal pulsatile pattern. Its selectivity is the reason it is often called the selective secretagogue: older ghrelin mimetics such as GHRP-6 and GHRP-2 also raise cortisol, ACTH and prolactin and, in the case of GHRP-6, strongly stimulate appetite, whereas ipamorelin does not to any notable degree. Compared with sermorelin and tesamorelin, which are GHRH analogues, ipamorelin acts on a different receptor and is used to study the ghrelin arm of the axis rather than the GHRH arm.

Specifications

Available sizes and pricing

Ipamorelin is supplied in a single 10mg vial. At about 712 g/mol, 10mg corresponds to roughly 14 micromoles, which is ample for extended cell-based or small-animal work. Researchers who want ipamorelin already paired with a GHRH analogue can choose the CJC-1295 No DAC and Ipamorelin blend, which contains 5mg of each peptide in one vial for $139.99.

• 10mg vial — $89.99 (about $9.00 per mg)

Quality and COA verification

Every batch of ipamorelin is independently tested by Janoshik Analytical. HPLC is used to confirm purity at or above 99% and mass spectrometry is used to confirm that the material has the correct molecular mass for ipamorelin, which distinguishes it from other pentapeptide and hexapeptide secretagogues such as GHRP-2 and GHRP-6. A Certificate of Analysis is issued for every batch and published in our COA library, so the result for the vial you receive can be matched to its batch number. The peptide is supplied as a lyophilised powder in a sealed sterile vial for stability in storage and transit, and each order is packed securely and discreetly for domestic delivery within Australia.

Frequently bought together

• CJC-1295 No DAC + Ipamorelin Blend (10mg) — $139.99, ipamorelin pre-combined with a short-acting GHRH analogue for dual-pathway models
• CJC-1295 (DAC) (5mg) — $89.99, the long-acting GHRH analogue for sustained-signal comparisons
• Sermorelin (5mg) — $89.99, the unmodified GHRH(1-29) reference compound for the GHRH arm of the axis
• Bacteriostatic Water (10mL) — $29.99, the recommended diluent for reconstituting lyophilised peptides

Research guides

• CJC-1295 and Ipamorelin research guide
• How to reconstitute peptides
• How to store lyophilised peptides
• COA testing explained
• Peptide reconstitution calculator

Frequently asked questions

What is Ipa?
Ipa is the common shorthand for ipamorelin, and it is the name most people use when they pair it with CJC-1295 as cjc/ipa. It refers to the same selective growth hormone secretagogue described on this page, a synthetic pentapeptide that activates the ghrelin receptor. Whether it is written as Ipa, ipamorelin or the misspelling ipamoralin, it is the same compound supplied here as a lyophilised research peptide.

What is Ipamorelin?
Ipamorelin is a synthetic five-amino-acid peptide developed by Novo Nordisk as a growth hormone secretagogue. It activates the ghrelin receptor GHS-R1a on pituitary cells to trigger growth hormone release, and it was the first agonist in its class shown to do so without meaningful effects on cortisol, ACTH or prolactin. Omega Peptides Australia supplies it as a COA-verified lyophilised powder in a 10mg vial for in-vitro laboratory research only.

What is Ipamorelin also known as?
It is often shortened to Ipa, written as ipamorelin peptide, or misspelled ipamoralin, ipamorelon, ipamoreline, ipamorellin or ipamorlin. Its development code at Novo Nordisk was NNC 26-0161, and chemical suppliers may list it as ipamorelin acetate, which is the salt form of the same peptide. Its CAS number is 170851-70-4. It is also the ipamorelin half of the widely used CJC-1295 and ipamorelin combination.

How does Ipamorelin work?
Ipamorelin binds the growth hormone secretagogue receptor GHS-R1a on pituitary somatotrophs. The receptor activates phospholipase C, which raises intracellular calcium and triggers release of stored growth hormone. In the hypothalamus it also stimulates GHRH neurons and lowers somatostatin output. Its half-life is about two hours, so it produces a discrete growth hormone pulse, and it does this without the cortisol, ACTH and prolactin release seen with older ghrelin mimetics.

What does the research show about Ipamorelin?
Preclinical studies and early clinical pharmacology reported growth hormone release comparable to GHRP-6 with no notable change in cortisol, ACTH or prolactin. Rodent studies have examined bone formation and body composition, including in glucocorticoid-treated animals, and a Phase 2 programme investigated post-operative ileus before being discontinued for insufficient efficacy. Current research uses ipamorelin as the selective ghrelin-receptor reference compound and as the ghrelin-pathway partner in combination models.

Can I buy Ipamorelin at Chemist Warehouse or a pharmacy in Australia?
No. Ipamorelin is not a registered medicine in Australia and is not stocked by Chemist Warehouse, Priceline or any other retail pharmacy. The ipamorelin supplied here is a research-grade lyophilised compound with an independent batch Certificate of Analysis, intended for laboratory use, and it is not a pharmacy product.

Can Australian compounding pharmacies supply Ipamorelin?
Ipamorelin has in the past been among the peptides some Australian compounding pharmacies prepared on prescription. Compounding is only permitted for an individual patient on a valid prescription from a registered prescriber, within Pharmacy Board and TGA rules, and the TGA has stepped up compliance action on unapproved peptide products. Omega Peptides Australia is not a pharmacy. We supply the lyophilised research compound with a batch COA for in-vitro laboratory work only.

How do you reconstitute Ipamorelin?
Use bacteriostatic water. Let the vial reach room temperature, then add the water slowly down the inside wall so it runs onto the powder without splashing. Swirl gently until the powder dissolves, do not shake. Ipamorelin dissolves readily and gives a clear solution. Store the reconstituted vial at 2 to 8°C and use it within 28 days. Our reconstitution calculator will work out the concentration for any volume of water.

How should Ipamorelin be stored?
Keep sealed lyophilised vials at 2 to 8°C for short-term storage or at minus 20°C for long-term storage, protected from light and moisture, and avoid repeated freeze-thaw cycles. The dry powder is stable for extended periods under these conditions. After reconstitution, store the solution in the refrigerator at 2 to 8°C and use within 28 days.

Where can I buy Ipamorelin in Australia?
Ipamorelin can be ordered directly from Omega Peptides Australia. Stock is held domestically, orders placed before 12pm are dispatched the same day with tracked shipping, and every batch has an independent Janoshik COA available in our library. GHRH analogues and other secretagogues for comparative work are listed in our range of research peptides in Australia.

What does Ipamorelin cost in Australia?
Ipamorelin is $89.99 for a 10mg vial, which works out at about $9.00 per mg. If your study also needs a GHRH analogue, the CJC-1295 No DAC and Ipamorelin blend supplies 5mg of ipamorelin and 5mg of Modified GRF (1-29) in one vial for $139.99, and CJC-1295 DAC is available separately at $89.99 for 5mg.

How do I get Ipamorelin online in Australia?
Select the 10mg vial on this page, add it to your cart and complete checkout. Orders ship from our Australian stock with tracked domestic delivery in discreet packaging, and orders placed before 12pm on a business day are dispatched the same day. Because the product ships from within Australia there is no customs clearance or import paperwork and delivery times are short.

Is Ipamorelin legal in Australia?
Omega Peptides Australia supplies ipamorelin strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine or supplement. Purchasers are responsible for ensuring their intended use complies with all applicable laws.

Why is Ipamorelin called the selective secretagogue compared with GHRP-2 and GHRP-6?
All three activate the ghrelin receptor and release growth hormone, but GHRP-6 and GHRP-2 also stimulate cortisol, ACTH and prolactin release, and GHRP-6 in particular strongly stimulates appetite. Ipamorelin was engineered to keep the growth hormone response while dropping those off-target effects, which is why it is described as selective and why it is preferred when a study needs a clean ghrelin-receptor signal.

Is Ipamorelin available in Australia?
Yes, as a research-grade lyophilised peptide from domestic suppliers. Omega Peptides Australia holds Ipamorelin 10mg in Australian stock, COA verified, with same-day dispatch before 12pm.

Can you get Ipamorelin in Australia?
Yes, from an Australian research peptide supplier holding domestic stock. Omega Peptides Australia ships Ipamorelin from within Australia on tracked delivery with the batch COA published before purchase.

⚠ For in-vitro research and laboratory use only. Not for human or veterinary use.