Dihexa Capsules

Dihexa Capsules (60 caps) — Angiotensin IV-Derived HGF/c-Met Research Compound

Dihexa Capsules (60 x 10mg) is stocked in Australia by Omega Peptides Australia and dispatched the same business day on orders before 12pm, each batch backed by an independent certificate of analysis. Also searched as dihexa oral or PNB-0408 capsules, it is the oral capsule format of the angiotensin IV-derived HGF mimetic.

Dihexa Capsules contain the same compound as our lyophilised Dihexa vial, N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide, presented as 60 capsules of 10mg each for laboratories running oral research models. Dihexa is a small, metabolically stable derivative of angiotensin IV developed in a United States university neuroscience programme, with a hexanoyl cap, tyrosine, isoleucine and an aminohexanoic amide tail that together resist peptidase cleavage. It was first reported under the code PNB-0408 and is often written as Dihexa oral, dihexa caps or PNB-0408 capsules.

Dihexa is studied for synaptogenesis and dendritic spine formation in cultured neurons, for memory and learning in rodent models of induced cognitive deficit, and for neuroprotection in models of dopaminergic neuron loss. It is reported to bind hepatocyte growth factor (HGF) with picomolar affinity and to promote the HGF dimerisation that activates the c-Met receptor tyrosine kinase, a pathway that supports neuronal survival and synaptic connectivity. Its reported oral activity in rodents is the reason a capsule format exists.

Omega Peptides Australia supplies Dihexa Capsules as a high-purity (≥99% HPLC) COA-verified research compound in a sealed bottle of 60 capsules. Orders placed before 12pm are dispatched the same day from within Australia, and the certificate for each batch is published in our COA library.

Key research areas

• Oral rodent behavioural models Dihexa is one of the few peptide-derived research compounds reported to be active after oral administration in rats. The capsule format supplies a defined 10mg quantity per unit and removes the need to reconstitute and store a solution for long-duration studies.
• Memory and learning Rodent studies using scopolamine-induced cholinergic deficits and aged animals have examined Dihexa in spatial tasks such as the Morris water maze, reporting improved acquisition and recall.
• Synaptogenesis and dendritic spine density In cultured hippocampal neurons, Dihexa increases dendritic spine number and functional synapse formation at very low concentrations. For concentration-defined in-vitro work the lyophilised vial is the more precise format.
• HGF/c-Met signalling Dihexa acts as an HGF mimetic, and researchers use it to study how c-Met signalling shapes neuronal survival, neurite outgrowth and plasticity.
• Neurodegeneration models Dihexa has been examined in rodent models of dopaminergic neuron loss that mimic aspects of Parkinson's disease, with attention to neuronal survival and motor behaviour. Longer oral protocols are a main reason laboratories choose the 60-capsule format.

How Dihexa works

Hepatocyte growth factor must dimerise to activate its receptor, c-Met, a tyrosine kinase expressed on neurons and many other cell types. Dihexa is reported to bind HGF and stabilise the active dimer, lowering the HGF concentration needed to trigger c-Met signalling. Activated c-Met switches on the PI3K/Akt and MAPK/ERK cascades, promoting cell survival, cytoskeletal remodelling and the formation of new synaptic contacts. Because the compound amplifies an endogenous ligand rather than replacing it, its activity in a given tissue depends on the HGF present there.

What sets Dihexa apart from peptides such as Semax or Selank is its physical chemistry. At about 505 daltons with a fatty-acid cap, it is lipophilic, resistant to aminopeptidases and carboxypeptidases, and described in rodent research as orally active and able to cross the blood-brain barrier. Those properties make an oral capsule a rational research format, whereas a conventional short peptide would simply be digested. The capsules contain the identical compound to the vial, 10mg of Dihexa per capsule in an inert excipient base.

Specifications

Available sizes and pricing

Dihexa Capsules are supplied in a single bottle size. With 600mg of compound per bottle, the capsule format is the lowest per-milligram option for Dihexa and suits protocols that consume more than a 10mg vial provides.

• 60 capsules (10mg each) — $399.99 (about $6.67 per capsule, about $0.67 per mg)

Multi-vial pricing: 2 vials $719.98 (10% off, $359.99 each), 3 vials $1,049.97 (12.5% off, $349.99 each), 4 vials $1,359.97 (15% off, $339.99 each). The discount is applied automatically in the cart.

For in-vitro work, the Dihexa 10mg lyophilised vial is $169.99.

Quality and COA verification

Every batch of Dihexa used in our capsules is tested independently by Janoshik Analytical, with HPLC confirming purity against the ≥99% specification and mass spectrometry confirming that the observed mass matches the expected 504.67 g/mol. A Certificate of Analysis is issued for every lot and published in our COA library, where the batch number on your bottle can be matched to its report. Capsules are filled from verified material, sealed in a tamper-evident research bottle with a desiccant, and packed for domestic transit; the dry format is less sensitive to temperature fluctuations than a solution.

Frequently bought together

• Dihexa (10mg) — $169.99, the lyophilised vial for cell-culture and concentration-defined work
• Semax (10mg) — $79.99, a BDNF-pathway nootropic peptide used as a mechanistic comparator
• Cerebrolysin (60mg) — $269.99, a neurotrophic peptide mixture studied alongside single-target compounds

Research guides

• Peptide storage guide: how to store lyophilised peptides properly
• COA testing explained
• Peptide reconstitution calculator
• Certificates of Analysis library

Frequently asked questions

What are Dihexa Capsules?
Dihexa Capsules are an oral research format of Dihexa, the angiotensin IV-derived compound N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide, supplied as 60 capsules of 10mg each. The compound activates the HGF/c-Met pathway and has been studied in cultured neurons and rodent models for synapse formation, memory and neuroprotection. The capsules are supplied strictly for laboratory research and are not a supplement or medicine.

What are Dihexa Capsules also known as?
They are also listed as Dihexa oral, dihexa caps, Dihexa 10mg capsules or PNB-0408 capsules, after the compound's original development code. The active compound is the same molecule found in our lyophilised vial and appears in chemical catalogues as Hexanoyl-Tyr-Ile-Ahx-NH2 or N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide under CAS number 1401708-83-5.

How does Dihexa work?
Dihexa binds hepatocyte growth factor and stabilises it in the dimeric form that activates the c-Met receptor tyrosine kinase. Activated c-Met signals through PI3K/Akt and MAPK/ERK to support neuronal survival, neurite growth and the formation of dendritic spines and synapses. Its lipophilic, protease-resistant structure allows it to remain active after oral administration in rodent studies.

What does the research show about Dihexa?
Preclinical studies report that Dihexa increases dendritic spine density and functional synapses in cultured hippocampal neurons at very low concentrations, and improves spatial learning in rats with scopolamine-induced deficits and in aged animals, including after oral administration. Rodent models of dopaminergic neuron loss have also been examined. There are no published human clinical trials.

Can I buy Dihexa Capsules at Chemist Warehouse or a pharmacy in Australia?
No. Dihexa is not a registered medicine in any country, is not listed on the Australian Register of Therapeutic Goods, and is not stocked by Chemist Warehouse, Priceline or any other retail pharmacy in any form. Dihexa Capsules are available in Australia only from research suppliers, as a laboratory research compound for in-vitro and animal-model use.

Can Australian compounding pharmacies supply Dihexa?
Australian compounding pharmacies may only prepare medicines for an individual patient on prescription, and the TGA has warned of significant uncertainties around compounded unapproved peptides not described in recognised compounding references. Dihexa has no such reference and no clinical data, so it is not a compounding product. Research suppliers such as Omega Peptides Australia supply the research compound, in vial or capsule form, for laboratory use only.

Do Dihexa Capsules need to be reconstituted?
No. Unlike the lyophilised vial, the capsules require no bacteriostatic water, syringes or reconstitution; each capsule contains a fixed 10mg of Dihexa in an inert base. If a laboratory needs the compound in solution, the lyophilised vial is the better choice: it is dissolved in bacteriostatic water at a defined concentration, swirled gently, refrigerated at 2–8°C and used within 28 days.

How should Dihexa Capsules be stored?
Keep the bottle tightly sealed in a cool, dry place below 25°C, away from direct light and moisture, and leave the desiccant in place. Refrigeration is not required for the capsule format. Avoid humid environments, because moisture uptake is the main risk to capsule stability. Stored correctly, the capsules remain within specification for the shelf life on the batch label.

Where can I buy Dihexa Capsules in Australia?
Omega Peptides Australia holds Dihexa Capsules in domestic stock, dispatches orders placed before 12pm the same day, and provides a batch Certificate of Analysis for every bottle. Ordering domestically avoids international transit delays and customs uncertainty. The capsules sit alongside our other neuropeptides in the research peptides Australia collection.

What do Dihexa Capsules cost in Australia?
A bottle of 60 capsules (10mg each, 600mg in total) is $399.99, which is about $6.67 per capsule or $0.67 per mg. By comparison, the 10mg lyophilised vial is $169.99, or about $17.00 per mg, so the capsules are the economical choice where a protocol consumes larger quantities. Prices are in Australian dollars and include third-party batch testing.

How do I get Dihexa Capsules online in Australia?
Add the 60-capsule bottle to your cart on this page and complete checkout. Orders are shipped with tracked domestic delivery in discreet packaging with no reference to the contents. Orders placed before 12pm on a business day are dispatched the same day; later orders leave the next business day, and tracking details are emailed once the parcel is lodged.

Are Dihexa Capsules legal in Australia?
Omega Peptides Australia supplies Dihexa Capsules strictly for lawful in-vitro laboratory research. Dihexa is not approved by the TGA for human or veterinary use and is not sold as a medicine or supplement. Purchasers are responsible for ensuring their intended use complies with all applicable laws.

Dihexa Capsules vs the lyophilised vial: which should I choose?
Choose the lyophilised vial for cell-culture and any in-vitro work that needs a precisely prepared solution at a defined concentration. Choose the capsules for oral rodent models and long-duration protocols where reconstitution is impractical and larger quantities are needed; at 600mg per bottle they are far cheaper per milligram. Both formats contain the same compound tested to the same ≥99% purity specification.

⚠ For in-vitro research and laboratory use only. Not for human or veterinary use.