Hexarelin

Hexarelin (5mg) — Synthetic Hexapeptide Growth Hormone Secretagogue Research Peptide

Hexarelin (5mg) is supplied in Australia by Omega Peptides Australia from domestic stock, with same-day dispatch on orders placed before 12pm and an independent certificate of analysis for every batch. Commonly written as examorelin, hexarelin peptide or GHRP, it is a hexapeptide growth hormone secretagogue studied for ghrelin receptor activation.

Hexarelin is a synthetic six-amino-acid peptide of the growth hormone releasing peptide (GHRP) family. It was derived from GHRP-6 by replacing the D-tryptophan at position two with 2-methyl-D-tryptophan, a change that makes the molecule more resistant to enzymatic breakdown and gives it a stronger, longer action at its receptor. Its sequence is written His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys with a C-terminal amide. In the pharmacology literature it is called examorelin, and researchers also refer to it as hexarelin peptide, hex peptide or simply hex.

Hexarelin is studied in three main directions: as a potent stimulus of pituitary growth hormone release in endocrine models, as a ligand for the CD36 scavenger receptor in preclinical cardiovascular research, and as a comparator against the more selective secretagogues such as ipamorelin when researchers map the balance between GH release and other pituitary hormones. At the receptor level it is an agonist of the growth hormone secretagogue receptor type 1a (GHS-R1a), the same G-protein-coupled receptor that the stomach hormone ghrelin uses, and it triggers a rise in intracellular calcium that releases growth hormone from somatotroph cells.

Omega Peptides Australia supplies hexarelin as a high-purity (≥99% HPLC) COA-verified lyophilised powder in a sealed 5mg vial. Orders placed before 12pm are dispatched the same day from stock held within Australia, and the batch Certificate of Analysis for every lot is published in our COA library so identity and purity can be checked against the batch number on the label before the vial is opened.

Key research areas

• Growth hormone release potency. Hexarelin is one of the most potent GHRPs on a per-molecule basis in pituitary cell and animal models, producing a larger GH pulse than GHRP-6 from which it was derived. It is used as a high-ceiling reference compound when researchers characterise the GH-releasing capacity of a new secretagogue or a modified receptor.
• Cardiovascular and CD36 research. Beyond the ghrelin receptor, hexarelin binds CD36, a scavenger receptor expressed in cardiac muscle and macrophages. Preclinical rodent models have examined its effects on cardiac contractility, ischaemia-reperfusion injury and cardiomyopathy, with a growing body of evidence that some of these actions are independent of growth hormone.
• Receptor selectivity mapping. Hexarelin stimulates GH strongly but also produces transient rises in cortisol, ACTH and prolactin in the models studied. Comparing it with ipamorelin, which releases GH with little effect on those hormones, lets researchers dissect which parts of the GHS-R1a signalling cascade drive each response.
• Desensitisation and tachyphylaxis. Repeated exposure to hexarelin in animal and cell models leads to a gradual reduction in the GH response, a well-documented feature of the potent GHRPs. This makes it a useful compound for studying receptor downregulation, internalisation and recovery kinetics.
• Synergy with GHRH analogues. Because hexarelin acts on GHS-R1a and GHRH analogues act on the GHRH receptor, combining the two in a research model produces a GH pulse larger than either alone. Sermorelin, CJC-1295 and tesamorelin are the usual partners in this kind of experiment.
• Appetite and gastric signalling. As a ghrelin mimetic, hexarelin engages the same hypothalamic circuits that regulate feeding and gastric motility. Its orexigenic effect is generally reported as milder than GHRP-6, and it is used in feeding-behaviour and energy-balance models for that reason.

How Hexarelin works

Hexarelin is a synthetic agonist at the growth hormone secretagogue receptor type 1a (GHS-R1a), which is expressed on pituitary somatotrophs and in the hypothalamus. Binding activates the Gq protein pathway: phospholipase C generates inositol trisphosphate, calcium is released from intracellular stores and protein kinase C is activated, and the resulting calcium surge triggers exocytosis of growth hormone granules. In the hypothalamus the same receptor increases GHRH neuron activity and reduces somatostatin tone, so the pituitary receives a stronger releasing signal and less inhibition at the same time. That dual site of action is why GHRPs and GHRH analogues are additive when studied together.

The 2-methyl-D-tryptophan substitution that distinguishes hexarelin from GHRP-6 slows its degradation and gives it a reported plasma half-life of roughly 50 minutes in the published pharmacology, compared with about 20 minutes for GHRP-6 and about 30 minutes for GHRP-2. Hexarelin is also unusual among the GHRPs in binding the CD36 scavenger receptor, which underlies its distinct cardiovascular research profile. Against ipamorelin, the key difference is selectivity: ipamorelin releases GH with minimal effect on cortisol, ACTH or prolactin, while hexarelin is more potent but less selective. Against MK-677 (ibutamoren), which is a non-peptide GHS-R1a agonist with a half-life of several hours, hexarelin is short-acting and peptide-based.

Specifications

Available sizes and pricing

Hexarelin is supplied in a single 5mg vial size. Because it is a short hexapeptide with a molecular weight under 900 g/mol, 5mg contains a high molar quantity of peptide, and the vial will support many assays at typical research concentrations. The price is per vial, with the per-milligram figure shown for comparison against the GHRP-2 and GHRP-6 10mg vials. Laboratories setting up for the first time can add the Research Starter Kit for bacteriostatic water, syringes and swabs in one pack.

• 5mg vial — $89.99 (about $18.00 per mg)

Quality and COA verification

Each batch of hexarelin is tested independently by Janoshik Analytical before release. The HPLC purity assay quantifies the intact hexapeptide against any deletion sequences or oxidised tryptophan impurities, and mass spectrometry confirms that the measured molecular mass matches the expected value for the six-residue sequence. A Certificate of Analysis is issued for every lot and published in our COA library, where it can be matched to the batch number on the vial label. The peptide is lyophilised for long-term stability, sealed in a sterile glass vial with a crimped cap, and packed with cushioning for domestic transit so the powder arrives dry and intact. Keeping the vial lyophilised until the moment of use preserves the tryptophan residues, which are the most oxidation-sensitive part of the molecule.

Frequently bought together

• Bacteriostatic Water (10mL) — $29.99, the recommended diluent for reconstituting lyophilised hexarelin.
• GHRP-6 (10mg) — $79.99, the parent hexapeptide from which hexarelin was derived, for potency and appetite comparisons.
• GHRP-2 (10mg) — $79.99, a second-generation GHRP for side-by-side receptor studies.
• Ipamorelin (10mg) — $89.99, the selective secretagogue used as the specificity comparator to hexarelin.

Research guides

• CJC-1295 and Ipamorelin research guide
• CJC-1295 and Ipamorelin research overview
• Peptide storage guide
• COA testing explained
• Peptide reconstitution calculator
• Certificates of Analysis library

Frequently asked questions

What is Hexarelin?
Hexarelin is a synthetic six-residue peptide in the growth hormone releasing peptide family. It was built from GHRP-6 by swapping the second residue for 2-methyl-D-tryptophan, which makes it more stable and more potent. It is studied as a ghrelin-receptor agonist that stimulates growth hormone release and as a CD36 ligand in cardiovascular models. It is supplied here as a lyophilised, COA-verified powder for in-vitro research only.

What is Hexarelin also known as?
The international non-proprietary name is examorelin, which is how it appears in pharmacology databases. It is also written as hexarelin peptide, hexarelin acetate, hex peptide or hex, and the common misspellings hexarellin, hexeralin and hexarilin all refer to the same molecule. Its full chemical description is L-histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide.

How does Hexarelin work?
Hexarelin activates the growth hormone secretagogue receptor type 1a, the same receptor targeted by ghrelin. In pituitary somatotrophs this triggers the Gq signalling cascade, raising intracellular calcium and releasing growth hormone. In the hypothalamus it increases GHRH output and suppresses somatostatin, adding a second stimulus. Separately, it binds the CD36 scavenger receptor in cardiac tissue, which is the basis of its preclinical cardiovascular research profile.

What does the research show about Hexarelin?
Published work in cell and animal models shows that hexarelin is among the most potent GHRPs at releasing growth hormone, that the response attenuates with repeated exposure, and that it also raises cortisol and prolactin transiently. Preclinical rodent studies have examined CD36-mediated effects on cardiac function and ischaemia-reperfusion injury. Everything described here comes from laboratory and preclinical research and does not relate to any use outside that setting.

Can I buy Hexarelin at Chemist Warehouse or a pharmacy in Australia?
No. Hexarelin is not registered on the Australian Register of Therapeutic Goods and has never been marketed as a medicine in Australia or elsewhere, so it is not stocked by Chemist Warehouse, Priceline or any other retail pharmacy. The lyophilised research-grade hexarelin sold here is a laboratory reagent supplied to researchers, not a pharmacy product, and it is not a substitute for any registered medicine.

Can Australian compounding pharmacies supply Hexarelin?
Compounding pharmacies in Australia may only prepare a medicine for a named patient on a practitioner's prescription and cannot sell peptides to the public. Research suppliers such as Omega Peptides Australia supply the lyophilised research compound for in-vitro laboratory use, which is a different product on a different pathway from anything a pharmacy prepares.

How do you reconstitute Hexarelin?
Use bacteriostatic water. Draw the required volume into a sterile syringe and add it slowly down the inside wall of the vial so the stream does not strike the lyophilised cake directly. Swirl gently until the solution is clear and do not shake, because agitation can denature the peptide. Refrigerate the reconstituted vial at 2–8°C and use it within 28 days. Our reconstitution calculator converts vial size and diluent volume into a concentration.

How should Hexarelin be stored?
Store the unopened lyophilised vial at 2–8°C for short-term use or at −20°C for long-term storage, protected from light and moisture and away from repeated freeze-thaw cycles. Once reconstituted, keep the solution at 2–8°C and use it within 28 days. Hexarelin contains two tryptophan residues that are sensitive to light and oxidation, so keeping the vial in its box and minimising the time it spends at room temperature helps preserve purity.

Where can I buy Hexarelin in Australia?
Omega Peptides Australia holds hexarelin in domestic stock and dispatches orders placed before 12pm on the same business day with tracked shipping within Australia. Each batch is backed by an independent Certificate of Analysis that you can review in the COA library before ordering. Hexarelin is listed alongside GHRP-2, GHRP-6 and ipamorelin in our research peptides range so related secretagogues can be compared on one page.

What does Hexarelin cost in Australia?
Hexarelin is supplied in a 5mg vial at $89.99, which is about $18.00 per milligram. There is currently no larger vial or bundle for this compound. Bacteriostatic water for reconstitution is sold separately at $29.99 for 10mL or $14.99 for 3mL, and the Research Starter Kit combines bacteriostatic water with syringes and alcohol swabs for laboratories ordering their first secretagogue.

How do I get Hexarelin online in Australia?
Open the hexarelin product page, select the 5mg vial, add it to the cart and complete checkout. Orders placed before 12pm are dispatched the same business day from our Australian stock and later orders leave on the next business day. Parcels are sent by tracked domestic courier in plain, discreet packaging with no product description on the outside, and a tracking number is emailed when the order ships.

Is Hexarelin legal in Australia?
Omega Peptides Australia supplies hexarelin strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine or supplement. Purchasers are responsible for ensuring their intended use complies with all applicable laws, including any state or territory requirements that apply to research chemicals.

Hexarelin vs GHRP-6 and Ipamorelin: what are the potency and selectivity differences in research?
All three act on GHS-R1a. GHRP-6 is the parent compound, with a strong appetite effect and a half-life of about 20 minutes. Hexarelin is its stabilised derivative, more potent at releasing GH, longer-acting at roughly 50 minutes, but also more likely to raise cortisol and prolactin and to desensitise with repeated exposure. Ipamorelin is the most selective, releasing GH with minimal effect on other hormones, at the cost of lower peak potency.

⚠ For in-vitro research and laboratory use only. Not for human or veterinary use.