Epitalon

Epitalon — Synthetic Pineal Tetrapeptide Ageing Research Compound

Epitalon (10mg) is stocked in Australia by Omega Peptides Australia and dispatched the same business day on orders before 12pm, each batch backed by an independent certificate of analysis. Also searched as Epithalon, AEDG, epitalon peptide or epithalamin, it is a synthetic tetrapeptide studied for telomerase activation and circadian regulation.

Epitalon is a synthetic tetrapeptide with the sequence alanine-glutamic acid-aspartic acid-glycine, written in single-letter code as AEDG. It was designed in St Petersburg by the research group of Vladimir Khavinson as a defined synthetic analogue of epithalamin, a polypeptide extract of the bovine pineal gland that had been studied in Russian gerontology for decades. At four residues and a molecular weight under 400 g/mol, it is one of the smallest peptides in the research catalogue. It is also spelled epithalon or epithalone, described as the AEDG peptide or Ala-Glu-Asp-Gly, and often called epitalon peptide.

Epitalon is studied in three main directions: the regulation of telomerase activity and telomere length in cultured human cells, the function of the pineal gland and melatonin rhythm in aged animals, and lifespan and tumour incidence in rodent and insect models. The proposed mechanism is that the short, highly charged peptide passes into the nucleus and binds to specific DNA sequences, changing the transcription of genes such as the telomerase catalytic subunit and regulators of cell differentiation, rather than acting on a cell-surface receptor.

Omega Peptides Australia supplies epitalon as a high-purity (≥99% HPLC), COA-verified lyophilised powder in 10mg and 50mg research vials. Orders placed before 12pm are dispatched the same day from within Australia, and the certificate for every batch is published in our COA library.

Key research areas

• Telomerase and telomere biology. In-vitro studies in cultured human somatic cells reported that epitalon induced expression of the telomerase catalytic subunit, increased telomerase activity and lengthened telomeres, extending the number of divisions before replicative senescence. This work is the origin of the peptide's reputation and remains the most cited research direction.
• Pineal function and melatonin rhythm. Studies in aged rhesus monkeys and rats examined whether epitalon restored the night-time peak of melatonin secretion and normalised circadian patterns of cortisol and other hormones, consistent with its origin as an analogue of a pineal extract.
• Lifespan and tumour incidence. Long-term rodent and Drosophila studies measured survival, spontaneous tumour rates and markers of biological age during chronic epitalon exposure. Results from these models are the basis of its classification as a geroprotective research peptide.
• Retinal degeneration. In a rat strain with hereditary retinal dystrophy, epitalon was studied for preservation of retinal structure and function, and this line of work continues in ocular ageing models.
• Gene expression and neurogenesis. Cell-culture studies examined changes in genes associated with neuronal differentiation and in chromatin markers after epitalon exposure, supporting the hypothesis that short peptides act as epigenetic regulators.
• Antioxidant defence. Epitalon has been investigated for effects on superoxide dismutase and glutathione peroxidase activity and on lipid peroxidation in tissues of aged animals, one of several proposed routes to the effects seen in ageing models.

Epitalon in Australia

Because Epitalon is not listed on the Australian Register of Therapeutic Goods, it cannot be bought from a pharmacy in Australia; retail chains do not carry it. The route in Australia is a domestic research supplier holding the compound as a research-grade lyophilised vial. Omega Peptides Australia keeps Epitalon in Australian stock and ships it the same business day for orders before 12pm, on tracked delivery, which removes the transit and customs delay of ordering from overseas. The batch certificate is published in the COA library so identity and purity can be checked before the order is placed.

Epitalon is stocked in Australia in 10mg and 50mg vials. It is often run in cellular-ageing designs alongside Thymalin or NAD+, both held in domestic stock.

How epitalon works

Epitalon does not behave like a classical hormone peptide with a defined membrane receptor. The working hypothesis from molecular modelling and cell studies is that the tetrapeptide, which carries two acidic residues, enters the cell and the nucleus and interacts directly with DNA in the major groove at specific short sequences, loosening chromatin and allowing transcription of otherwise silenced genes. The genes most often examined are the telomerase reverse transcriptase gene and genes involved in cell differentiation, and the reported downstream effect is an extension of the proliferative lifespan of cultured cells. Its influence on melatonin production is thought to arise from the same transcriptional regulation acting in pinealocytes.

As an unmodified four-residue peptide, epitalon is rapidly cleared by peptidases and has a short half-life in circulation, so research models usually involve repeated exposure over long periods. Epitalon is distinct from epithalamin, which is a complex natural extract with many components, and from thymalin, a thymus-derived preparation studied for immune function. It should be noted that most of the epitalon literature comes from one research group and awaits broad independent replication, which is part of why it remains a research compound rather than a medicine.

Specifications

Available sizes and pricing

Epitalon is supplied in two vial sizes. The 10mg vial is suited to pilot work and short cell-culture series, while the 50mg vial halves the per-mg cost and is the practical choice for the long-duration models that dominate epitalon research. Both sizes are drawn from the same COA-verified batches.

• 10mg vial — $79.99 (about $8.00 per mg)
• 50mg vial — $199.99 (about $4.00 per mg)

Quality and COA verification

Every batch of epitalon is independently tested by Janoshik Analytical. HPLC confirms purity of 99 percent or higher, and mass spectrometry confirms that the measured mass matches the expected 390.35 g/mol of the AEDG sequence, which rules out truncated or mis-synthesised peptides. A Certificate of Analysis is issued for every batch and published in our COA library, where the batch number on the vial can be matched to its report. The peptide is filled into sterile vials, sealed and lyophilised, because a dry powder is far more resistant to hydrolysis than a solution. Orders are packed to protect the vial during domestic transit and shipped from Australian stock so that time in transit is short.

Frequently bought together

• Bacteriostatic Water (10mL) — $29.99, the standard diluent for reconstituting lyophilised peptides.
• NAD+ (500mg) — $139.99, the coenzyme most often studied alongside epitalon in ageing models.
• Thymalin (10mg) — $89.99, a thymic peptide preparation from the same bioregulator research tradition.
• MOTS-C (10mg) — $99.99, a mitochondrial-derived peptide used in metabolic ageing research.

Research guides

• Peptide storage guide
• COA testing explained
• Peptide reconstitution calculator
• Ordering and shipping FAQs

Frequently asked questions

What is epitalon?
Epitalon is a synthetic tetrapeptide, Ala-Glu-Asp-Gly, created as a defined analogue of epithalamin, an extract of the pineal gland. It is studied in research models of telomerase activity, pineal melatonin rhythm, lifespan and retinal ageing. Omega Peptides Australia supplies it as a lyophilised research peptide in 10mg and 50mg vials for in-vitro laboratory use only, with an independent Certificate of Analysis for every batch.

What is epitalon also known as?
Epitalon is also spelled epithalon and epithalone, and it is described by its sequence as AEDG, Ala-Glu-Asp-Gly or the AEDG peptide. Many listings call it epitalon peptide or epithalon peptide. Its natural counterpart is epithalamin, the pineal extract it was designed to replace, and the two names are sometimes confused although they are different materials.

How does epitalon work?
Epitalon is thought to act inside the nucleus rather than at a receptor. Molecular modelling and cell studies suggest the peptide binds specific DNA sequences and relaxes chromatin, allowing transcription of genes such as telomerase reverse transcriptase. The reported result in cultured human cells is increased telomerase activity and longer telomeres. In whole animals it is also studied for restoring melatonin secretion from the aged pineal gland.

What does the research show about epitalon?
In-vitro studies reported telomerase activation and telomere lengthening in human fibroblasts. Rodent and primate studies reported restored melatonin rhythms, changes in antioxidant enzyme activity and, in long-term rodent experiments, differences in lifespan and spontaneous tumour incidence. Most of this evidence comes from a single research group, and independent replication is limited, which is why epitalon remains a research compound.

Can I buy epitalon at Chemist Warehouse or a pharmacy in Australia?
No. Epitalon is not a registered medicine in Australia and does not appear on the Australian Register of Therapeutic Goods, so Chemist Warehouse, Priceline and other retail pharmacies do not stock it. No epitalon medicine is approved anywhere in the world. Omega Peptides Australia supplies epitalon only as a research-grade lyophilised compound for in-vitro laboratory work, which is a different category of product from a pharmacy medicine.

Can Australian compounding pharmacies supply epitalon?
Australian compounding pharmacies may prepare a medicine only for an individual patient on a prescription from a registered practitioner, and the TGA has warned about the uncertainties of compounded unapproved peptide products. Epitalon is not an approved ingredient and is not a routine compounded product. Research suppliers such as Omega Peptides Australia supply the lyophilised research compound for laboratory use, which is separate from any pharmacy pathway.

How do you reconstitute epitalon?
Add bacteriostatic water slowly down the inside wall of the vial so it runs gently onto the powder, then swirl until the solution is clear. Do not shake. Epitalon is very water soluble and dissolves quickly. The reconstitution calculator gives the volume for a chosen concentration. Refrigerate the reconstituted vial at 2–8°C and use it within 28 days.

How should epitalon be stored?
Store the sealed lyophilised powder at 2–8°C for short-term use or at −20°C for long-term storage, protected from light and moisture, and avoid repeated freeze-thaw cycles. Small peptides such as epitalon are stable for extended periods in dry form when kept cold. After reconstitution, refrigerate the solution at 2–8°C and use it within 28 days, and avoid leaving the vial at room temperature.

Where can I buy epitalon in Australia?
Omega Peptides Australia holds epitalon in domestic stock and dispatches orders placed before 12pm on the same business day. Every batch is COA-verified by an independent laboratory and the certificates are published online. Order the 10mg or 50mg vial from this page, or browse the full range of research peptides in Australia for related ageing research compounds.

What does epitalon cost in Australia?
Research-grade epitalon from Omega Peptides Australia costs $79.99 for a 10mg vial, which is about $8.00 per mg, and $199.99 for a 50mg vial, which is about $4.00 per mg. The larger vial halves the per-mg cost. Bacteriostatic water for reconstitution is sold separately in 3mL and 10mL sizes.

How do I get epitalon online in Australia?
Select the 10mg or 50mg vial on this product page, add it to your cart and complete checkout. Orders are shipped with tracked domestic delivery in discreet, unbranded packaging. Orders placed before 12pm are dispatched the same business day from within Australia, and a tracking number is emailed once the parcel is lodged with the carrier.

Is epitalon legal in Australia?
Omega Peptides Australia supplies epitalon strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine or supplement. Purchasers are responsible for ensuring their intended use complies with all applicable laws.

Should I choose the 10mg or 50mg epitalon vial?
The 10mg vial suits short cell-culture experiments, method development and single-arm pilot studies where a small amount of peptide is used over a few weeks. The 50mg vial suits the long-duration and multi-arm models typical of ageing research, where the same batch must be used consistently over months, and it reduces the per-mg cost from about $8.00 to about $4.00. Reconstitute only what will be used within 28 days.

Is Epitalon available in Australia?
Yes, as a research-grade lyophilised peptide from domestic suppliers. Omega Peptides Australia holds Epitalon in 10mg and 50mg vials in Australian stock, COA verified, with same-day dispatch before 12pm.

Where can I buy Epithalon in Australia?
From an Australian research peptide supplier with domestic stock. Omega Peptides Australia dispatches Epitalon from within Australia on tracked delivery.

⚠ For in-vitro research and laboratory use only. Not for human or veterinary use.