SLU-PP-332

SLU-PP-332 (5mg) — Pan-ERR Agonist Exercise-Mimetic Research Compound

SLU-PP-332 (5mg) is supplied in Australia by Omega Peptides Australia from domestic stock, with same-day dispatch on orders placed before 12pm and an independent certificate of analysis for every batch. Commonly written as SLU PP 332, SLUPP332, SLU-PP332, ERR agonist or exercise mimetic, it is a pan-ERR agonist studied as an exercise mimetic in metabolic research.

SLU-PP-332 is a synthetic small molecule, not a peptide. Chemically it is a naphthalene hydrazide, N'-(naphthalen-2-ylmethylene)-4-hydroxybenzohydrazide, with a molecular weight of about 290 g/mol. It was characterised as an agonist of the estrogen-related receptors by a pharmacology group at Saint Louis University, from which it takes its SLU prefix, and the first reports of its activity in skeletal muscle and metabolic models appeared in 2023. It activates all three estrogen-related receptor isoforms, ERR alpha, ERR beta and ERR gamma, which is why it is called a pan-ERR agonist. It is written as SLU-PP-332, SLU PP 332 or slu pp332, and is widely described as an exercise mimetic compound.

SLU-PP-332 is studied for its ability to reproduce the transcriptional signature of endurance exercise in skeletal muscle, for its effects on energy expenditure and fat mass in diet-induced obesity models, and for mitochondrial biogenesis in muscle, heart and kidney. The estrogen-related receptors are orphan nuclear receptors that, together with the coactivator PGC-1 alpha, switch on the genes of oxidative phosphorylation, fatty acid oxidation and mitochondrial replication; a small-molecule agonist lets researchers activate that program without a physical training stimulus.

Omega Peptides Australia supplies SLU-PP-332 as a high-purity (≥99% HPLC), COA-verified lyophilised powder in a 5mg research vial. Orders placed before 12pm are dispatched the same day from within Australia, and the certificate for every batch is published in our COA library.

Key research areas

• Exercise mimicry in skeletal muscle. In mice, SLU-PP-332 increased the proportion of oxidative type IIa muscle fibres, raised mitochondrial DNA content and cytochrome c levels, and extended treadmill running time and distance without any training. Researchers use it to ask which benefits of endurance exercise can be reproduced by activating ERR-driven transcription alone.
• Energy expenditure and obesity. Studies in diet-induced obese mice reported reduced weight gain and fat mass, improved glucose tolerance and higher whole-body oxygen consumption during administration, with the effect attributed to increased fatty acid oxidation rather than reduced food intake.
• Mitochondrial biogenesis. ERR alpha and ERR gamma, with PGC-1 alpha, control the expression of hundreds of nuclear-encoded mitochondrial genes. Cell-culture work uses SLU-PP-332 to measure changes in mitochondrial respiration, biogenesis markers and oxidative capacity in myotubes and other cell types.
• Cardiac energetics. The heart depends on ERR signalling to maintain fatty acid oxidation, and ERR activity falls in heart failure. Preclinical models examine whether ERR agonism with SLU-PP-332 preserves cardiac mitochondrial function and contractile performance under pressure overload.
• Kidney ageing. Renal tubular cells are highly oxidative, and ERR expression declines with age in the kidney. Work in aged mice examined markers of glomerular integrity, including albumin handling and podocin expression, during pan-ERR agonism.
• Nuclear receptor pharmacology. Because the ERRs are orphan receptors with no known natural ligand, SLU-PP-332 is valuable simply as a chemical probe. Structure-activity work around its scaffold aims to separate the three isoforms and to improve pharmacokinetic properties for longer studies.

SLU-PP-332 in Australia

SLU-PP-332 is not registered on the Australian Register of Therapeutic Goods, so it is not stocked by Chemist Warehouse, Priceline or other pharmacies. In Australia it is supplied as a research-grade lyophilised vial by domestic research suppliers. Omega Peptides Australia holds SLU-PP-332 in stock within Australia and dispatches orders placed before 12pm the same business day on tracked domestic delivery, so material arrives in days rather than waiting on an international shipment and customs. Every batch is tested independently and its certificate is published in the COA library before the vial ships.

SLU-PP-332 is stocked in Australia as a 5mg vial. It sits alongside 5-Amino-1MQ and MOTS-C in the metabolic research range held domestically.

How SLU-PP-332 works

The estrogen-related receptors are transcription factors related in structure to the estrogen receptor but which do not bind estrogen. They are constitutively active and are regulated mainly by the availability of coactivators, above all PGC-1 alpha, whose levels rise during exercise, cold exposure and fasting. SLU-PP-332 binds the ligand-binding pocket of all three isoforms and stabilises the conformation that recruits coactivators, with reported half-maximal effective concentrations of roughly 98, 230 and 430 nanomolar for ERR alpha, beta and gamma respectively. The activated receptor complex then binds ERR response elements in the promoters of genes encoding respiratory chain subunits, fatty acid transporters and oxidative enzymes.

The net effect in muscle cells is a shift toward an oxidative, endurance-type phenotype: more mitochondria, greater capacity to burn fat, and improved fatigue resistance. In rodent pharmacokinetic work the compound has a short plasma half-life, so in-vivo studies have relied on frequent administration, and this limitation drives ongoing analogue development. SLU-PP-332 is mechanistically distinct from 5-Amino-1MQ, which acts on an enzyme in NAD+ metabolism, and from MOTS-c, which signals through AMPK; it works one level higher, at the transcriptional switch that sets mitochondrial gene expression.

Specifications

Available sizes and pricing

SLU-PP-332 is supplied in a single 5mg research vial. The compound is active at nanomolar concentrations, so 5mg is sufficient for extensive cell-culture work or a small rodent series; laboratories running larger programs can order several vials from the same COA-verified batch so the material stays consistent throughout.

• 5mg vial — $149.99 (about $30.00 per mg)

Quality and COA verification

Every batch of SLU-PP-332 is independently tested by Janoshik Analytical. HPLC confirms purity of 99 percent or higher, and mass spectrometry confirms that the measured mass matches the expected 290.3 g/mol, which distinguishes the compound from synthetic intermediates and from the closely related hydrazide analogues used in structure-activity studies. A Certificate of Analysis is issued for every batch and published in our COA library, where the batch number on the vial can be matched to its report. The compound is filled into sterile vials, sealed and lyophilised, protecting it from moisture and light during storage. Orders are packed to protect the vial during domestic transit and shipped from Australian stock so that time in transit is short.

Frequently bought together

• 5-Amino-1MQ (5mg) — $89.99, a small-molecule NNMT inhibitor studied in the same metabolic models.
• MOTS-C (10mg) — $99.99, a mitochondrial-derived peptide that activates AMPK.
• AOD-9604 (5mg) — $89.99, a growth hormone fragment used in lipid metabolism research.
• Bacteriostatic Water (10mL) — $29.99, for diluting a DMSO stock into an aqueous working solution.

Research guides

• Peptide storage guide
• COA testing explained
• Peptide reconstitution calculator
• Ordering and shipping FAQs

Frequently asked questions

What is SLU-PP-332?
SLU-PP-332 is a synthetic small molecule that activates all three estrogen-related receptors, nuclear receptors that control the genes of mitochondrial biogenesis and fat oxidation. It is studied as an exercise mimetic because it reproduces part of the muscle adaptation to endurance training in rodents. Omega Peptides Australia supplies it as a lyophilised research compound in a 5mg vial, COA-verified, for in-vitro laboratory use only.

What is SLU-PP-332 also known as?
SLU-PP-332 is written as SLU PP 332, SLU-PP332 or slu pp332, and is described as the SLU-PP-332 ERR agonist or the exercise mimetic compound. Its chemical name is N'-(naphthalen-2-ylmethylene)-4-hydroxybenzohydrazide and its CAS number is 303760-60-3. The SLU prefix refers to Saint Louis University, where its receptor activity was characterised. It has no pharmaceutical brand name.

How does SLU-PP-332 work?
SLU-PP-332 binds the ligand pocket of ERR alpha, beta and gamma and stabilises the shape that recruits the coactivator PGC-1 alpha. The activated receptors then bind response elements in the promoters of genes for respiratory chain subunits, fatty acid transporters and oxidative enzymes. In muscle this produces more mitochondria, a shift toward oxidative fibres and greater fat-burning capacity, the same transcriptional program that endurance training switches on.

What does the research show about SLU-PP-332?
Rodent studies reported increased oxidative muscle fibres, higher mitochondrial content and longer treadmill endurance in untrained mice, and reduced fat mass, improved glucose tolerance and higher oxygen consumption in diet-induced obese mice. Cell studies showed increased mitochondrial respiration in muscle cell lines. All published work is preclinical; SLU-PP-332 has not been evaluated in human clinical trials.

Can I buy SLU-PP-332 at Chemist Warehouse or a pharmacy in Australia?
No. SLU-PP-332 is not a registered medicine in Australia and does not appear on the Australian Register of Therapeutic Goods, so Chemist Warehouse, Priceline and other retail pharmacies do not stock it. No ERR agonist is an approved medicine anywhere in the world. Omega Peptides Australia supplies SLU-PP-332 only as a research-grade lyophilised compound for in-vitro laboratory work, which is a different category of product from a pharmacy medicine.

Can Australian compounding pharmacies supply SLU-PP-332?
Australian compounding pharmacies may prepare a medicine only for an individual patient on a prescription from a registered practitioner, and SLU-PP-332 is a preclinical research compound with no approved pharmaceutical use, so it is not a compounded product. Research suppliers such as Omega Peptides Australia supply the lyophilised research compound for laboratory use, which is separate from any pharmacy or clinical pathway.

How do you reconstitute SLU-PP-332?
SLU-PP-332 is a lipophilic small molecule and does not dissolve freely in water, so it is handled differently from peptides. Dissolve the powder first in a small volume of DMSO to make a concentrated stock, with brief sonication if needed, then dilute the stock into aqueous buffer or bacteriostatic water for the working solution, keeping the final DMSO content low. Prepare aqueous dilutions fresh and keep the DMSO stock frozen at −20°C.

How should SLU-PP-332 be stored?
Store the sealed lyophilised powder at 2–8°C for short-term use or at −20°C for long-term storage, protected from light and moisture, and avoid repeated freeze-thaw cycles. Once dissolved, keep the DMSO stock at −20°C in small aliquots and use it within 28 days, or freeze at −80°C for longer holds. Aqueous dilutions should be made fresh on the day of use.

Where can I buy SLU-PP-332 in Australia?
Omega Peptides Australia holds SLU-PP-332 in domestic stock and dispatches orders placed before 12pm on the same business day. Every batch is COA-verified by an independent laboratory and the certificates are published online. Order the 5mg vial from this page, or browse the full range of research peptides in Australia for related metabolic research compounds.

What does SLU-PP-332 cost in Australia?
Research-grade SLU-PP-332 from Omega Peptides Australia costs $149.99 for a 5mg vial, which is about $30.00 per mg. Because the compound is active at nanomolar concentrations, one vial covers a large number of cell-culture experiments. DMSO for the stock solution is a standard laboratory reagent, and bacteriostatic water for aqueous dilution is sold separately in 3mL and 10mL sizes.

How do I get SLU-PP-332 online in Australia?
Add the 5mg vial to your cart on this product page and complete checkout. Orders are shipped with tracked domestic delivery in discreet, unbranded packaging. Orders placed before 12pm are dispatched the same business day from within Australia, and a tracking number is emailed once the parcel is lodged with the carrier.

Is SLU-PP-332 legal in Australia?
Omega Peptides Australia supplies SLU-PP-332 strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine or supplement. Purchasers are responsible for ensuring their intended use complies with all applicable laws.

How does SLU-PP-332 compare with 5-Amino-1MQ?
Both are small-molecule metabolic research compounds rather than peptides, but they act at different points. SLU-PP-332 is a nuclear receptor agonist that switches on the transcription of mitochondrial and fat-oxidation genes, reproducing an exercise-like program in muscle. 5-Amino-1MQ inhibits the enzyme NNMT, raising cellular NAD+ and SAM and reducing fat synthesis in adipocytes. Researchers studying energy balance often use them in parallel models.

Is SLU-PP-332 available in Australia?
Yes, as a research-grade compound from domestic suppliers. Omega Peptides Australia holds SLU-PP-332 5mg in Australian stock, COA verified, with same-day dispatch before 12pm.

Where can I buy SLU PP 332 in Australia?
From an Australian research supplier with domestic stock. Omega Peptides Australia dispatches SLU-PP-332 from within Australia on tracked delivery.

⚠ For in-vitro research and laboratory use only. Not for human or veterinary use.