Adamax

Adamax (10mg) — Adamantane-Modified Semax Analogue Research Peptide

Adamax is a synthetic research peptide described as an adamantane-modified analogue of Semax, the heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro. Semax itself was built from the ACTH(4-7) fragment of adrenocorticotropic hormone with a Pro-Gly-Pro extension added at the C-terminus to slow enzymatic breakdown, and it has been studied in Russian laboratories for several decades. Adamax takes that backbone and, according to supplier descriptions, attaches an adamantyl group, the rigid cage-shaped hydrocarbon found in compounds such as amantadine and memantine. It is often written as Adamax peptide, ADMAX or adamax nootropic peptide, and is sometimes described as an adamantane Semax analogue or adamantylated Semax.

Adamax is investigated in the same research directions as its parent peptide: neurotrophic signalling, particularly brain-derived neurotrophic factor (BDNF) expression, learning and memory performance in rodent models, and neuroprotection under ischaemic or oxidative stress. The Semax family is thought to act by raising BDNF and its receptor TrkB in the hippocampus and by modulating monoamine and enkephalin systems, while the adamantane group is intended to increase lipophilicity and resistance to peptidases so that the molecule persists longer in tissue.

Omega Peptides Australia supplies Adamax as a high-purity (≥99% HPLC) COA-verified lyophilised powder in a sealed sterile 10mg vial. Orders placed before 12pm are dispatched the same day from within Australia, and the batch certificate for every lot is published in our COA library.

Key research areas

• Neurotrophic signalling Semax has been shown in rodent studies to increase BDNF and TrkB expression in the hippocampus within hours of administration. Adamax is studied to establish whether the adamantane substitution preserves or amplifies that neurotrophic response in cultured neurons and rodent brain tissue, and whether the effect persists longer because of slower peptidase clearance.
• Learning and memory The Semax lineage has been examined in rodent behavioural tasks such as passive avoidance and maze learning, where melanocortin fragments are associated with improved acquisition and retention. Adamax is investigated as a comparator in the same paradigms, with the working hypothesis that a more lipophilic analogue may reach central targets more efficiently.
• Neuroprotection Semax has been studied in models of cerebral ischaemia and retinal or optic nerve injury, where it is associated with reduced neuronal loss and altered expression of genes involved in inflammation and apoptosis. Adamax is examined for the same protective profile, with attention to whether the adamantyl group changes tissue distribution during hypoxic stress.
• Stress and anxiety-related behaviour ACTH-derived fragments modulate the hypothalamic-pituitary-adrenal axis and anxiety-like behaviour in rodents without producing classical corticosteroid release. Adamax is studied in elevated plus maze and open field paradigms to determine whether the modified peptide shares this anxiolytic-type profile.
• Endurance and recovery Supplier literature describes Adamax as being of interest for physical endurance and recovery from strenuous exertion. This claim does not yet appear in peer-reviewed research and should be treated as a hypothesis for rodent exercise models rather than an established finding.
• Structure-activity relationships Because Semax, N-Acetyl Semax and Adamax share a backbone and differ only in their terminal or lipophilic modifications, the three are used together in comparative studies of peptide stability, blood-brain barrier passage and potency, helping researchers understand how small chemical changes alter the behaviour of melanocortin-derived peptides.

How Adamax works

Adamax is expected to act through the same pathways as Semax. Semax is a melanocortin-derived heptapeptide that does not behave as a classical agonist at melanocortin receptors; instead, it has been reported to raise BDNF and nerve growth factor expression, increase TrkB receptor levels in the hippocampus, modulate serotonergic and dopaminergic transmission, and inhibit enzymes that degrade enkephalins. Together these actions are proposed to underpin the memory, attention and neuroprotective findings reported in rodent and in-vitro research. Adamax retains the Semax backbone, so its research rationale rests on those established mechanisms.

What distinguishes Adamax is the adamantane cage. Adamantane is highly lipophilic and sterically bulky, which in medicinal chemistry is used to improve membrane penetration and to shield adjacent bonds from enzymatic cleavage. Native Semax is degraded quickly by peptidases, with a half-life measured in minutes, and N-Acetyl Semax addresses this with an acetyl group on the N-terminus. Adamax pursues the same goal with a larger lipophilic modification. No peer-reviewed pharmacokinetic data for Adamax have been published, so its actual half-life and distribution in research models remain to be characterised, and each batch is confirmed by HPLC purity and mass spectrometry identity rather than by a published reference monograph.

Specifications

Available sizes and pricing

Adamax is supplied in a single 10mg research vial. Because the compound is a specialist modified analogue rather than a mass-produced peptide, the per-milligram cost is higher than Semax, which we also stock for laboratories comparing the two.

• 10mg vial — $159.99 (about $16.00 per mg)

Laboratories building a nootropic peptide panel may also consider the Semax and Selank Bundle, which pairs the parent peptide with Selank at a bundle price.

Quality and COA verification

Every batch of Adamax is tested independently by Janoshik Analytical, with HPLC used to quantify purity and mass spectrometry used to confirm molecular identity. A Certificate of Analysis is issued for every lot, and the current batch certificate can be viewed in our COA library before or after purchase. Because Adamax has no published pharmacopoeial monograph, the mass spectrometry identity check is particularly important, and we will not release a batch that does not match the expected mass. The peptide is lyophilised to protect it from hydrolysis during storage, sealed in a sterile vial under an inert environment, and packed with cushioning for domestic transit so that it arrives ready for laboratory use.

Frequently bought together

• Semax (10mg) — $79.99, the parent heptapeptide, essential as a comparator in any Adamax study
• N-Acetyl Semax (10mg) — $129.99, the acetylated analogue for structure-activity comparisons
• Dihexa (10mg) — $169.99, a mechanistically distinct HGF/c-Met research compound often studied alongside melanocortin peptides
• Bacteriostatic Water (10mL) — $29.99, for reconstituting the lyophilised powder

Research guides

• Semax Australia research guide
• Peptide storage guide: how to store lyophilised peptides properly
• COA testing explained
• Peptide reconstitution calculator
• Certificates of Analysis library

Frequently asked questions

What is Adamax?
Adamax is a synthetic research peptide built on the Semax backbone, Met-Glu-His-Phe-Pro-Gly-Pro, with an adamantane group added to increase lipophilicity and enzymatic stability. Semax is an ACTH(4-7) fragment analogue that has been studied for neurotrophic and cognitive effects in rodent models, and Adamax is investigated as a longer-lasting variant of that peptide. It is supplied as a lyophilised powder strictly for in-vitro research and laboratory use.

What is Adamax also known as?
It is also written as Adamax peptide, ADMAX or adamax nootropic peptide, and is often described as an adamantane Semax analogue, adamantylated Semax or adamantane-modified Semax. Some listings group it with the broader family of ACTH(4-10) fragment analogues. It should not be confused with Semax or N-Acetyl Semax, which are separate compounds with their own specifications.

How does Adamax work?
Adamax is expected to share the mechanism of Semax, which raises BDNF and TrkB expression in the hippocampus, modulates serotonergic and dopaminergic signalling, and inhibits enkephalin-degrading enzymes in rodent research. The adamantane cage is intended to protect the peptide from peptidase cleavage and improve membrane penetration, so that these actions last longer. Direct pharmacokinetic studies of Adamax have not yet been published.

What does the research show about Adamax?
Peer-reviewed research on Adamax itself is very limited, so most of the evidence base comes from Semax, which has been studied in rodent models of memory, cerebral ischaemia and stress and in Russian clinical programmes as a nasal formulation. Supplier reports of enhanced BDNF response and endurance in Adamax have not been independently confirmed. Researchers typically treat Adamax as an experimental analogue to be characterised against Semax in their own models.

Can I buy Adamax at Chemist Warehouse or a pharmacy in Australia?
No. Adamax is not a registered medicine on the Australian Register of Therapeutic Goods and is not stocked by Chemist Warehouse, Priceline or any other retail pharmacy. The same applies to its parent peptide Semax, which is registered only in Russia and a small number of other countries. In Australia, Adamax is available only as a research-grade lyophilised compound from laboratory suppliers, for in-vitro use.

Can Australian compounding pharmacies supply Adamax?
Compounding pharmacies in Australia may only prepare a medicine for an individual patient against a prescription, and the TGA has highlighted significant uncertainties with compounded unapproved peptides whose active ingredients are not described in recognised compounding references. Adamax has no such reference and no pharmacopoeial monograph, so it is not a compounding product. Research suppliers such as Omega Peptides Australia supply the lyophilised research compound for laboratory use only.

How do you reconstitute Adamax?
Use bacteriostatic water. Draw the required volume with a sterile syringe and add it slowly down the inside wall of the vial rather than directly onto the powder. Swirl gently until the solution is clear; never shake, as agitation can denature the peptide. Adamax is more lipophilic than Semax, so allow a little extra time for it to dissolve. Refrigerate the reconstituted vial at 2–8°C and use within 28 days.

How should Adamax be stored?
Keep the lyophilised vial sealed at 2–8°C for short-term storage or at −20°C for long-term storage, protected from light and moisture. Avoid repeated freeze-thaw cycles, which degrade peptides more quickly than steady cold storage. Once reconstituted, store the solution in the refrigerator at 2–8°C and use it within 28 days. Our storage guide covers handling in more detail.

Where can I buy Adamax in Australia?
Omega Peptides Australia supplies Adamax from domestic stock, with orders placed before 12pm dispatched the same day and a batch COA available for every vial. Ordering from an Australian supplier avoids customs delays and the temperature swings of international transit. You can browse Adamax alongside our other neuropeptides in the research peptides Australia collection.

What does Adamax cost in Australia?
Adamax is priced at $159.99 for a 10mg vial, which is about $16.00 per mg. The higher per-milligram cost compared with Semax at $79.99 reflects the additional synthesis steps required for the adamantane modification and the smaller production volumes of this analogue. All prices are in Australian dollars and include a batch Certificate of Analysis.

How do I get Adamax online in Australia?
Select the 10mg vial on this product page, add it to your cart and complete checkout. Orders are shipped with tracked domestic delivery in discreet packaging with no external reference to the contents. Orders placed before 12pm on a business day are dispatched the same day; later orders leave the next business day. You will receive tracking details by email once the parcel is lodged.

Is Adamax legal in Australia?
Omega Peptides Australia supplies Adamax strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine or supplement. Purchasers are responsible for ensuring their intended use complies with all applicable laws.

Adamax vs Semax and N-Acetyl Semax: what is the difference?
All three share the Met-Glu-His-Phe-Pro-Gly-Pro backbone. Semax is the original, best-studied peptide. N-Acetyl Semax adds an acetyl group to the N-terminus, which slows enzymatic degradation and is the form most often used in newer research. Adamax adds a bulky adamantane group intended to increase lipophilicity and stability further, but it has the smallest published evidence base of the three. Laboratories usually run Semax as the reference compound when evaluating either analogue.

⚠ For in-vitro research and laboratory use only. Not for human or veterinary use.