5-amino-1-mq

5-Amino-1MQ — Selective NNMT Inhibitor Metabolic Research Compound

Omega Peptides Australia supplies 5-Amino-1MQ (5mg) in Australia from domestic stock, dispatching same day on orders placed before 12pm with a certificate of analysis published for every batch. Often written 5 amino 1MQ, 5-amino-1-MQ, amino 1MQ or NNMT inhibitor, it is a small-molecule NNMT inhibitor studied in adipocyte and metabolic research.

5-Amino-1MQ is a small molecule, not a peptide. Its full name is 5-amino-1-methylquinolinium: a quinoline ring carrying a methyl group on the ring nitrogen, which gives it a permanent positive charge, and an amino group at position 5. It was developed by a medicinal chemistry group at the University of Texas Medical Branch as a membrane-permeable, substrate-site inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). The compound is written as 5-Amino-1MQ, 5-amino-1-MQ, 5 amino 1mq or 5-amino-1-methylquinolinium, is often described simply as the NNMT inhibitor, and is shortened to 5-AMQ in laboratory discussion.

5-Amino-1MQ is studied for its effects on adipose tissue and body composition in diet-induced obesity models, on cellular NAD+ and S-adenosylmethionine (SAM) levels, and on the regeneration of aged skeletal muscle. NNMT consumes nicotinamide and SAM to make 1-methylnicotinamide, so blocking the enzyme spares both substrates: more nicotinamide is available to be recycled into NAD+ through the salvage pathway, and more SAM remains for methylation reactions and polyamine synthesis.

Omega Peptides Australia supplies 5-Amino-1MQ as a high-purity (≥99% HPLC), COA-verified lyophilised powder in 5mg and 50mg research vials. Orders placed before 12pm are dispatched the same day from within Australia, and the certificate for every batch is published in our COA library.

Key research areas

• Adipose tissue and diet-induced obesity. NNMT is strongly upregulated in the fat and liver of obese, insulin-resistant animals, and genetic knockdown of the enzyme protects mice from diet-induced weight gain. Studies with 5-Amino-1MQ in high-fat-fed mice examined fat mass, adipocyte size and plasma cholesterol without a change in food intake.
• Adipocyte lipogenesis. In cultured adipocytes the compound has been used to test whether NNMT inhibition reduces fat synthesis and lipid accumulation, with measurements of intracellular NAD+, SAM and the NNMT product 1-methylnicotinamide used to confirm on-target activity.
• NAD+ and methylation balance. Because NNMT sits at the junction of the NAD+ salvage pathway and the methionine cycle, 5-Amino-1MQ is a tool for studying how these two systems compete for nicotinamide and SAM, and how that competition changes sirtuin activity and gene methylation.
• Muscle regeneration in ageing. NNMT activity rises in aged skeletal muscle. Work in aged mice examined whether NNMT inhibition improved satellite cell activation and the repair of injured muscle, a research direction relevant to sarcopenia models.
• Cancer cell metabolism. NNMT is overexpressed in several tumour types, where it acts as a methyl sink that alters the epigenetic state of cancer cells and cancer-associated fibroblasts. Cell-line studies use 5-Amino-1MQ to probe the consequences of blocking that sink.
• Liver and metabolic disease. Hepatic NNMT expression correlates with fatty liver and insulin resistance in rodent and human samples, and inhibitor studies investigate gluconeogenesis, lipid handling and the response to a high-fat diet.

5-Amino-1MQ in Australia

5-Amino-1MQ is supplied in Australia strictly as a research-grade lyophilised vial; it is not a registered medicine and is not available through Chemist Warehouse, Priceline or compounding pharmacies. Omega Peptides Australia holds it in domestic stock, dispatches same day on orders before 12pm, and ships on tracked delivery within Australia, so there is no international transit or customs hold. Each batch carries an independent certificate in the COA library matched to the number printed on the vial.

5-Amino-1MQ is stocked in Australia in 5mg and 50mg sizes. It is frequently run with AOD-9604 or SLU-PP-332 in metabolic designs, both held domestically.

How 5-Amino-1MQ works

NNMT transfers a methyl group from S-adenosylmethionine to nicotinamide, producing 1-methylnicotinamide, which is excreted, and S-adenosylhomocysteine. In doing so it removes nicotinamide that would otherwise be recycled into NAD+ by NAMPT, and it consumes SAM that would otherwise methylate DNA, histones and other substrates. 5-Amino-1MQ occupies the nicotinamide-binding site of the enzyme and competes with the natural substrate, with a reported half-maximal inhibitory concentration in the low micromolar range and good selectivity over other enzymes of the NAD+ pathway. Because it carries a positive charge on a small aromatic scaffold, it crosses cell membranes and reaches the cytoplasmic enzyme.

Inhibiting NNMT raises intracellular NAD+ and SAM and lowers 1-methylnicotinamide, and in adipocytes this shift is associated with reduced lipogenesis and increased energy expenditure at the cellular level. 5-Amino-1MQ is therefore mechanistically distinct from NAD+ precursors such as NMN, which add substrate to the pathway rather than stopping its loss, and from ERR agonists such as SLU-PP-332, which act on nuclear receptors to drive mitochondrial gene expression. Its small size and water solubility make it straightforward to handle in cell-culture and rodent research.

Specifications

Available sizes and pricing

5-Amino-1MQ is supplied in two vial sizes. The 5mg vial is enough for enzyme assays and cell-culture work at micromolar concentrations, while the 50mg vial reduces the per-mg cost by more than half and suits rodent models or extended experimental series. Both sizes come from the same COA-verified batches.

• 5mg vial — $89.99 (about $18.00 per mg)
• 50mg vial — $389.99 (about $7.80 per mg)

Quality and COA verification

Every batch of 5-Amino-1MQ is independently tested by Janoshik Analytical. HPLC confirms purity of 99 percent or higher, and mass spectrometry confirms the identity of the quinolinium cation against its expected mass, which distinguishes it from related quinoline compounds and from synthetic by-products. A Certificate of Analysis is issued for every batch and published in our COA library, where the batch number printed on the vial can be matched to its report. The compound is filled into sterile vials, sealed and lyophilised, which protects it from moisture and light during storage. Orders are packed to protect the vial during domestic transit and shipped from Australian stock so that time in transit is short.

Frequently bought together

• Bacteriostatic Water (10mL) — $29.99, for dissolving the powder to a working stock.
• NAD+ (500mg) — $139.99, the coenzyme whose salvage pathway NNMT inhibition is designed to spare.
• MOTS-C (10mg) — $99.99, a mitochondrial-derived peptide studied in the same metabolic models.
• AOD-9604 (5mg) — $89.99, a growth hormone fragment used in lipid metabolism research.

Research guides

• Peptide storage guide
• COA testing explained
• Peptide reconstitution calculator
• Ordering and shipping FAQs

Frequently asked questions

What is 5-AMQ?
5-AMQ is a shorthand for 5-Amino-1MQ, the small-molecule NNMT inhibitor 5-amino-1-methylquinolinium. Searches for 5-AMQ, 5 amino 1mq or 5-amino-1-MQ all refer to the same compound. Omega Peptides Australia supplies it as a lyophilised research compound in 5mg and 50mg vials, with an independent Certificate of Analysis for every batch, for in-vitro laboratory use only.

What is 5-Amino-1MQ?
5-Amino-1MQ is a synthetic quinolinium small molecule that selectively inhibits nicotinamide N-methyltransferase, the enzyme that methylates nicotinamide and removes it from the NAD+ salvage pathway. It was developed as a research tool for studying obesity, adipose metabolism and NAD+ biology. Unlike most compounds in this catalogue it is not a peptide, but it is handled and stored in the same way.

What is 5-Amino-1MQ also known as?
The chemical name is 5-amino-1-methylquinolinium. It is written as 5-Amino-1MQ, 5-amino-1-MQ, 5 amino 1mq or 5-AMQ, and it is often referred to simply as the NNMT inhibitor or NNMTi. Chemical suppliers list it under CAS 42464-96-0 as the iodide salt. All of these names describe the same positively charged quinoline compound.

How does 5-Amino-1MQ work?
5-Amino-1MQ binds the nicotinamide site of NNMT and blocks the transfer of a methyl group from SAM to nicotinamide. This stops the formation of 1-methylnicotinamide and leaves more nicotinamide available for conversion to NAD+ and more SAM available for methylation. In adipocytes the resulting rise in NAD+ and SAM is associated with lower fat synthesis, and the compound crosses cell membranes easily because of its small charged structure.

What does the research show about 5-Amino-1MQ?
Preclinical studies in high-fat-fed mice reported reduced body weight, fat mass and adipocyte size during 5-Amino-1MQ administration with no change in food intake, alongside lower plasma cholesterol. Cell studies confirmed reduced lipogenesis and increased NAD+ and SAM. Work in aged mice examined improved muscle regeneration after injury. These are laboratory findings; the compound has not entered human clinical trials.

Can I buy 5-Amino-1MQ at Chemist Warehouse or a pharmacy in Australia?
No. 5-Amino-1MQ is not a registered medicine in Australia and is not listed on the Australian Register of Therapeutic Goods, so Chemist Warehouse, Priceline and other retail pharmacies do not stock it. No NNMT inhibitor is an approved medicine anywhere in the world. Omega Peptides Australia supplies 5-Amino-1MQ only as a research-grade lyophilised compound for in-vitro laboratory work, which is a different category of product from a pharmacy medicine.

Can Australian compounding pharmacies supply 5-Amino-1MQ?
Australian compounding pharmacies may prepare a medicine only for an individual patient on a prescription from a registered practitioner, and 5-Amino-1MQ is an experimental compound with no approved pharmaceutical use, so it is not a routine compounded product. Research suppliers such as Omega Peptides Australia supply the lyophilised research compound for laboratory use, which is separate from any pharmacy or clinical pathway.

How do you reconstitute 5-Amino-1MQ?
Add bacteriostatic water slowly down the inside wall of the vial and swirl gently until the powder dissolves; do not shake. As a small charged salt, 5-Amino-1MQ dissolves readily in water. The reconstitution calculator gives the volume needed for a target concentration. Refrigerate the reconstituted vial at 2–8°C, protect it from light and use it within 28 days.

How should 5-Amino-1MQ be stored?
Store the sealed lyophilised powder at 2–8°C for short-term use or at −20°C for long-term storage, protected from light and moisture, and avoid repeated freeze-thaw cycles. Quinolinium compounds are light sensitive, so keep the vial in its box or a dark container. After reconstitution, refrigerate the solution at 2–8°C and use it within 28 days.

Where can I buy 5-Amino-1MQ in Australia?
Omega Peptides Australia holds 5-Amino-1MQ in domestic stock and dispatches orders placed before 12pm on the same business day. Every batch is COA-verified by an independent laboratory and the certificates are published online. Order the 5mg or 50mg vial from this page, or browse the full range of research peptides in Australia for related metabolic compounds.

What does 5-Amino-1MQ cost in Australia?
Research-grade 5-Amino-1MQ from Omega Peptides Australia costs $89.99 for a 5mg vial, which is about $18.00 per mg, and $389.99 for a 50mg vial, which is about $7.80 per mg. The larger vial cuts the per-mg cost by more than half. Bacteriostatic water for reconstitution is sold separately in 3mL and 10mL sizes.

How do I get 5-Amino-1MQ online in Australia?
Select the 5mg or 50mg vial on this product page, add it to your cart and complete checkout. Orders are shipped with tracked domestic delivery in discreet, unbranded packaging. Orders placed before 12pm are dispatched the same business day from within Australia, and a tracking number is emailed once the parcel is lodged with the carrier.

Is 5-Amino-1MQ legal in Australia?
Omega Peptides Australia supplies 5-Amino-1MQ strictly for lawful in-vitro laboratory research. It is not approved by the TGA for human or veterinary use and is not sold as a medicine or supplement. Purchasers are responsible for ensuring their intended use complies with all applicable laws.

Should I choose the 5mg or 50mg 5-Amino-1MQ vial?
Because 5-Amino-1MQ is active at low micromolar concentrations, 5mg is enough for enzyme inhibition assays and several plates of cell-culture work, making it the sensible starting size for method development. The 50mg vial suits rodent models, multi-arm studies and laboratories that want a single batch across a whole program, and it lowers the per-mg cost from about $18.00 to about $7.80. Reconstitute only what will be used within 28 days.

Is 5-Amino-1MQ available in Australia?
Yes, as a research-grade compound from domestic suppliers. Omega Peptides Australia holds 5-Amino-1MQ in 5mg and 50mg in Australian stock, COA verified, with same-day dispatch before 12pm.

Where can I buy 5 Amino 1MQ in Australia?
From an Australian research supplier with domestic stock. Omega Peptides Australia dispatches 5-Amino-1MQ from within Australia on tracked delivery.

⚠ For in-vitro research and laboratory use only. Not for human or veterinary use.