What is MOTS-C?

MOTS-C (Mitochondrial ORF of the Twelve S rRNA type-C) is a small peptide of 16 amino acids that is encoded within mitochondrial DNA rather than the cell nucleus. It belongs to a class known as mitochondrial-derived peptides, and it has become a significant focus of metabolic and cellular-signalling research since its identification. It is supplied strictly for laboratory research use only.

How MOTS-C is studied

In research models, MOTS-C is most associated with the AMPK pathway, a central regulator of cellular energy balance. Through this and related pathways it has been studied for effects on glucose handling, insulin sensitivity, and metabolic adaptation. A distinctive feature reported in the literature is that MOTS-C appears to act as a signal between the mitochondria and the cell nucleus, which is why it is often described in the context of metabolic stress response research.

Key research areas include:

• AMPK activation and cellular energy metabolism
• Glucose regulation and insulin-sensitivity research
• Exercise and physical-capacity research models
• Metabolic adaptation and mitochondrial signalling
• Age-related metabolic research

MOTS-C research findings

MOTS-C first drew attention through work published in Cell Metabolism (Lee et al., 2015), which described its role in promoting metabolic homeostasis via AMPK. Later research published in Nature Communications (Reynolds et al., 2021) reported that MOTS-C behaves as an exercise-induced, mitochondrial-encoded regulator of metabolic adaptation. These findings are reported strictly within controlled research settings.

Handling and reconstitution

MOTS-C is supplied lyophilised to support stability. For laboratory preparation, researchers typically reconstitute with a sterile diluent such as bacteriostatic water, following the relevant protocol. It is available in 10mg and 40mg research vials.

Storage considerations

• Store the lyophilised vial at −20°C
• Keep sealed and protected from heat, moisture and light
• Avoid repeated freeze-thaw cycles
• Record preparation dates after reconstitution

Research-grade MOTS-C: what to look for

Quality documentation is essential when sourcing MOTS-C. A reliable supplier should provide a third-party Certificate of Analysis, verified purity, clear labelling and research-use-only disclaimers. Omega Peptides Australia supplies MOTS-C for laboratory research as a COA-verified lyophilised powder.

MOTS-C in Australia

MOTS-C is not available through pharmacies or standard therapeutic channels in Australia and may only be supplied by specialist research compound suppliers for laboratory research. You can buy MOTS-C in Australia from Omega Peptides Australia with COA verification and fast domestic dispatch.

You can also browse the full range of research peptides for sale in Australia from Omega Peptides Australia.

Frequently Asked Questions

What is MOTS-C?

MOTS-C is a 16-amino-acid mitochondrial-derived peptide studied in metabolic research, particularly around the AMPK energy-regulation pathway.

What is MOTS-C studied for?

It is studied in glucose regulation, insulin-sensitivity, exercise and metabolic-adaptation research models. It is supplied strictly for laboratory research use only.

What vial sizes are available?

MOTS-C is supplied in 10mg and 40mg research vials.

How should MOTS-C be stored?

Store the lyophilised vial at −20°C, away from light and moisture, and avoid repeated freeze-thaw cycles.

Where can I buy MOTS-C in Australia?

Directly from Omega Peptides Australia, with COA verification and fast domestic dispatch.

References

• Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 2015.
• Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 2021.